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    nasp nuclear autoantigenic sperm protein (histone-binding) [ Danio rerio (zebrafish) ]

    Gene ID: 799570, updated on 9-Dec-2024

    Summary

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    Official Symbol
    naspprovided by ZNC
    Official Full Name
    nuclear autoantigenic sperm protein (histone-binding)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5511
    See related
    Ensembl:ENSDARG00000039208 AllianceGenome:ZFIN:ZDB-GENE-030131-5511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56007; zgc:85651; wu:fd20g12
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in CENP-A containing chromatin assembly and DNA replication-dependent chromatin assembly. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including eye; immature eye; pectoral fin; pharyngeal arch; and ventricular zone. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nasp in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (33911154..33916788, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (33926464..33932098, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 17 Neighboring gene coiled-coil domain containing 17 Neighboring gene aldo-keto reductase family 1, member A1b (aldehyde reductase) Neighboring gene pre-mRNA processing factor 38A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential gene expression and biomarkers in zebrafish (Danio rerio) following exposure to produced water components. Holth TF, et al. Aquat Toxicol, 2008 Dec 11. PMID 18963085
    2. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article
    3. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56007, MGC85651

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear autoantigenic sperm protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199782.2 → NP_956076.2  nuclear autoantigenic sperm protein

      Status: VALIDATED

      Source sequence(s)
      CR854855, EH441964, EH457062, EH473871, EH482784
      UniProtKB/TrEMBL
      A0A8M1PBV7, F1QNE0
      Related
      ENSDARP00000117697.1, ENSDART00000138488.3
      Conserved Domains (3) summary
      sd00006
      Location:381 → 415
      TPR; TPR repeat [structural motif]
      pfam10516
      Location:386 → 423
      SHNi-TPR; SHNi-TPR
      pfam13424
      Location:385 → 460
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      33911154..33916788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476951.2 → XP_021332626.1  nuclear autoantigenic sperm protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9QAI4
      Conserved Domains (2) summary
      sd00006
      Location:381 → 415
      TPR; TPR repeat [structural motif]
      cl26511
      Location:106 → 514
      Neuromodulin_N; Gap junction protein N-terminal region

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395259.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      216467..222069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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