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    uba2 ubiquitin-like modifier activating enzyme 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uba2provided by ZNC
    Official Full Name
    ubiquitin-like modifier activating enzyme 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2681
    See related
    Ensembl:ENSDARG00000101332 AllianceGenome:ZFIN:ZDB-GENE-040426-2681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sae2; sae2b; uble1b; zgc:66354; wu:fi17g06
    Summary
    Predicted to enable SUMO activating enzyme activity. Acts upstream of or within several processes, including fin morphogenesis; regulation of cartilage development; and regulation of neural retina development. Predicted to be located in nucleus. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in forebrain neural rod; head; nervous system; pectoral fin bud; and somite. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See uba2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (12811315..12824635, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (12714915..12728135, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 5 Neighboring gene carbonic anhydrase Va Neighboring gene chemokine (C-C motif) ligand 33, duplicate 3 Neighboring gene chemokine (C-C motif) ligand 33, duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. UBA2 variants underlie a recognizable syndrome with variable aplasia cutis congenita and ectrodactyly. Schnur RE, et al. Genet Med, 2021 Sep. PMID 34040189, Free PMC Article
    2. Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation. Dhliwayo N, et al. Diabetes, 2014 Sep. PMID 24722243, Free PMC Article
    3. Insights into the evolution of the ISG15 and UBA7 system. Liu S, et al. Genomics, 2022 Mar. PMID 35134494
    4. Chemokine C-C motif ligand 33 is a key regulator of teleost fish barbel development. Zhou T, et al. Proc Natl Acad Sci U S A, 2018 May 29. PMID 29760055, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SUMO activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SUMO activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aminoacyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of neural retina development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SUMO activating enzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SUMO activating enzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-activating enzyme subunit 2
    Names
    SUMO1 activating enzyme subunit 2
    SUMO1 activating enzyme subunit 2b
    ubiquitin-like 1 (sentrin) activating enzyme E1B
    ubiquitin-like 1-activating enzyme E1B
    NP_998528.1
    XP_009296132.1
    XP_009296133.1
    XP_068073455.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213363.1 → NP_998528.1  SUMO-activating enzyme subunit 2

      See identical proteins and their annotated locations for NP_998528.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055614
      UniProtKB/Swiss-Prot
      A7MCK7, B0S543, B0S544, Q7SXG4
      UniProtKB/TrEMBL
      B2GQ09
      Related
      ENSDARP00000130924.1, ENSDART00000169126.2
      Conserved Domains (5) summary
      cd01489
      Location:20 → 439
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:16 → 176
      ThiF; ThiF family
      pfam10585
      Location:180 → 357
      UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
      pfam14732
      Location:447 → 533
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:544 → 628
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      12811315..12824635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217354.1 → XP_068073455.1  SUMO-activating enzyme subunit 2 isoform X3

      UniProtKB/Swiss-Prot
      A7MCK7, B0S543, B0S544, Q7SXG4

    2. XM_009297858.4 → XP_009296133.1  SUMO-activating enzyme subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      A7MCK7, B0S543, B0S544, Q7SXG4
      UniProtKB/TrEMBL
      A0A8M3ANZ0
      Conserved Domains (5) summary
      cd01489
      Location:20 → 440
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:16 → 176
      ThiF; ThiF family
      pfam10585
      Location:180 → 358
      UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
      pfam14732
      Location:448 → 534
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:545 → 628
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

    3. XM_009297857.4 → XP_009296132.1  SUMO-activating enzyme subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      A7MCK7, B0S543, B0S544, Q7SXG4
      UniProtKB/TrEMBL
      A0A8M3AWE5
      Conserved Domains (5) summary
      cd01489
      Location:20 → 440
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:16 → 176
      ThiF; ThiF family
      pfam10585
      Location:180 → 358
      UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
      pfam14732
      Location:448 → 534
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:545 → 629
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395190.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      117484..136943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXG4.2 GenPept UniProtKB/Swiss-Prot:Q7SXG4

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