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    has3 hyaluronan synthase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 282555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    has3provided by ZNC
    Official Full Name
    hyaluronan synthase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021118-1
    See related
    Ensembl:ENSDARG00000057210 AllianceGenome:ZFIN:ZDB-GENE-021118-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dg42III; af190743gs2; xx:af190743gs1; xx:af190743gs2
    Summary
    Predicted to enable hyaluronan synthase activity. Predicted to be involved in extracellular matrix assembly; extracellular polysaccharide biosynthetic process; and hyaluronan biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in hypochord; median fin fold; nervous system; otic vesicle; and pectoral fin. Orthologous to human HAS3 (hyaluronan synthase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See has3 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17024139..17037412, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17037566..17048310, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) Neighboring gene TBC1 domain family, member 15 Neighboring gene CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) Neighboring gene transport and golgi organization 6 homolog (Drosophila) Neighboring gene interleukin 17c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ancient origin of lubricated joints in bony vertebrates. Askary A, et al. Elife, 2016 Jul 19. PMID 27434666, Free PMC Article
    2. Retinoic acid signaling regulates late stages of semicircular canal morphogenesis and otolith maintenance in the zebrafish inner ear. Mackowetzky K, et al. Dev Dyn, 2022 Nov. PMID 35710880
    3. Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Munjal A, et al. Cell, 2021 Dec 22. PMID 34942099, Free PMC Article
    4. Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. Govindan J, et al. PLoS One, 2016. PMID 26828861, Free PMC Article
    5. Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Bakkers J, et al. Development, 2004 Feb. PMID 14729574

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hyaluronan synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hyaluronan synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hyaluronan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hyaluronan synthase 3
    NP_775327.2
    XP_009291796.1
    XP_068070811.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173220.2 → NP_775327.2  hyaluronan synthase 3

      Status: VALIDATED

      Source sequence(s)
      BX950194
      UniProtKB/TrEMBL
      A0A8M1PDY9, Q1LUE8
      Related
      ENSDARP00000074268.3, ENSDART00000079817.5
      Conserved Domains (2) summary
      cd06434
      Location:82 → 364
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
      TIGR04242
      Location:11 → 466
      nodulat_NodC; chitooligosaccharide synthase NodC

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      17024139..17037412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214710.1 → XP_068070811.1  hyaluronan synthase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M1PDY9, Q1LUE8

    2. XM_009293521.4 → XP_009291796.1  hyaluronan synthase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AJI3
      Conserved Domains (2) summary
      cd06434
      Location:85 → 367
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
      TIGR04242
      Location:14 → 469
      nodulat_NodC; chitooligosaccharide synthase NodC

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395338.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      232419..235521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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