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    qdpra quinoid dihydropteridine reductase a [ Danio rerio (zebrafish) ]

    Gene ID: 566323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qdpraprovided by ZNC
    Official Full Name
    quinoid dihydropteridine reductase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-197
    See related
    Ensembl:ENSDARG00000040190 AllianceGenome:ZFIN:ZDB-GENE-070705-197
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-89f22.2
    Summary
    Predicted to enable 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Acts upstream of or within L-phenylalanine metabolic process and melanin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in eye; liver; melanoblast; and presumptive retinal pigmented epithelium. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See qdpra in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (46876360..46897044, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (47889279..47909963, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene LIM domain binding 2a Neighboring gene uncharacterized LOC137487623 Neighboring gene uncharacterized LOC137487503 Neighboring gene follistatin-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis. Breuer M, et al. PLoS One, 2019. PMID 30995231, Free PMC Article
    2. Evolution of pigment synthesis pathways by gene and genome duplication in fish. Braasch I, et al. BMC Evol Biol, 2007 May 11. PMID 17498288, Free PMC Article
    3. Toxicogenomic analysis in the combined effect of tributyltin and benzo[a]pyrene on the development of zebrafish embryos. Huang L, et al. Aquat Toxicol, 2015 Jan. PMID 25438121
    4. Pigmentation pathway evolution after whole-genome duplication in fish. Braasch I, et al. Genome Biol Evol, 2009 Nov 25. PMID 20333216, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 6,7-dihydropteridine reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6,7-dihydropteridine reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-phenylalanine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within melanin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    quinoid dihydropteridine reductase a
    Names
    dhpra
    NP_001103939.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110469.1 → NP_001103939.1  quinoid dihydropteridine reductase a

      See identical proteins and their annotated locations for NP_001103939.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115316
      UniProtKB/TrEMBL
      A0A8M1NGL6, A7YT77
      Related
      ENSDARP00000058788.5, ENSDART00000058789.7
      Conserved Domains (2) summary
      cd05334
      Location:4 → 226
      DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs
      PRK12828
      Location:7 → 222
      PRK12828; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      46876360..46897044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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