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    ddx19b DEAD-box helicase 19b [ Danio rerio (zebrafish) ]

    Gene ID: 192339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddx19bprovided by ZNC
    Official Full Name
    DEAD-box helicase 19bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-30
    See related
    Ensembl:ENSDARG00000005699 AllianceGenome:ZFIN:ZDB-GENE-020419-30
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ddx19; fi21a04; chunp6915; wu:fb24g07; wu:fc59e08; wu:fd14f03; wu:fi21a04
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in cytoplasmic stress granule and nucleus. Orthologous to several human genes including DDX19A (DEAD-box helicase 19A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ddx19b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3524737..3535500, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3505350..3516113, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3b Neighboring gene pseudouridine synthase like 1 Neighboring gene si:dkey-33m11.7 Neighboring gene calcium/calmodulin dependent protein kinase II inhibitor 1 Neighboring gene si:dkey-33m11.8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Jao LE, et al. Proc Natl Acad Sci U S A, 2013 Aug 20. PMID 23918387, Free PMC Article
    2. Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins. von Moeller H, et al. Nucleic Acids Res, 2013 Sep. PMID 23804756, Free PMC Article
    3. Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Li Z, et al. Environ Pollut, 2020 Jul. PMID 32146360
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX19B
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)
    DEAD/H box polypeptide 19
    NP_775365.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173258.1 → NP_775365.1  ATP-dependent RNA helicase DDX19B

      See identical proteins and their annotated locations for NP_775365.1

      Status: PROVISIONAL

      Source sequence(s)
      AY099536
      UniProtKB/TrEMBL
      Q7ZU28, Q8JGR1
      Related
      ENSDARP00000003250.4, ENSDART00000009788.7
      Conserved Domains (3) summary
      PTZ00424
      Location:99 → 477
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:315 → 450
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:102 → 304
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      3524737..3535500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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