prdm9 PR domain containing 9 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prdm9provided by ZNC
Official Full Name: PR domain containing 9provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1319
See related: Ensembl:ENSDARG00000005382 AllianceGenome:ZFIN:ZDB-GENE-040426-1319
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63970
Summary: Predicted to enable protein homodimerization activity; protein-lysine N-methyltransferase activity; and recombination hotspot binding activity. Predicted to be involved in several processes, including male gamete generation; meiosis I; and positive regulation of fertilization. Predicted to act upstream of or within chromatin organization; meiotic cell cycle; and methylation. Predicted to be located in chromosome. Predicted to be active in nucleus. Orthologous to human PRDM9 (PR/SET domain 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (9781524..9790464, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (9743681..9752621, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone H3K36 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K4 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20me methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables recombination hotspot binding	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair involved in meiotic recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in female gamete generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in homologous chromosome pairing at meiosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gamete generation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase PRDM9

Names: PR domain zinc finger protein 9; PR domain-containing protein 9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9; protein-lysine N-methyltransferase PRDM9

NP_957196.1

EC 2.1.1.354

EC 2.1.1.355

EC 2.1.1.359

EC 2.1.1.361

EC 2.1.1.362

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200902.1 → NP_957196.1 histone-lysine N-methyltransferase PRDM9

See identical proteins and their annotated locations for NP_957196.1

Status: PROVISIONAL

Source sequence(s)

BC064665

UniProtKB/Swiss-Prot

A5XCD9, Q6P2A1

Related

ENSDARP00000026323.8, ENSDART00000027321.10

Conserved Domains (3) summary

COG5048
Location:333 → 755

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:719 → 739

ZF_C2H2; C2H2 Zn finger [structural motif]

cd19193
Location:79 → 207

PR-SET_PRDM7_9; PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins