ckma creatine kinase, muscle a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ckmaprovided by ZNC
Official Full Name: creatine kinase, muscle aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-109
See related: Ensembl:ENSDARG00000035327 AllianceGenome:ZFIN:ZDB-GENE-980526-109
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ckm; mck; CK-M; cb51; wu:fa28d05
Summary: Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in extracellular space. Is expressed in brain; cardiovascular system; eye; and musculature system. Orthologous to human CKM (creatine kinase, M-type). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (36832081..36837841, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (36231928..36237688, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA606175/BR122 (e-PCR)
- UniSTS:206864

aa606175 (e-PCR)
- UniSTS:186912

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables creatine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphocreatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphocreatine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: creatine kinase, muscle a

NP_571007.2

EC 2.7.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130932.2 → NP_571007.2 creatine kinase, muscle a

Status: VALIDATED

Source sequence(s)

BX547938, EH439264, EH452882, EH471195

UniProtKB/TrEMBL

A0A8M1P6D9, A2BHA3

Related

ENSDARP00000037871.5, ENSDART00000032481.6

Conserved Domains (1) summary

cd00716
Location:17 → 373

creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes