U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mastl microtubule associated serine/threonine kinase-like [ Danio rerio (zebrafish) ]

    Gene ID: 445215, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mastlprovided by ZNC
    Official Full Name
    microtubule associated serine/threonine kinase-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-128
    See related
    Ensembl:ENSDARG00000055566 AllianceGenome:ZFIN:ZDB-GENE-040801-128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    GW; GWL; MAST-L; im:7149025; wu:fa02a12; zgc:100990
    Summary
    Predicted to enable protein phosphatase 2A binding activity and protein serine/threonine kinase activity. Acts upstream of or within thrombocyte differentiation. Predicted to be located in centrosome and cleavage furrow. Predicted to be active in nucleus. Is expressed in somite. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human MASTL (microtubule associated serine/threonine kinase like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mastl in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (5893134..5908247)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (5863805..5878918)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene procollagen C-endopeptidase enhancer 2b Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 63 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 64

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. In vivo inactivation of MASTL kinase results in thrombocytopenia. Johnson HJ, et al. Exp Hematol, 2009 Aug. PMID 19460416, Free PMC Article
    2. Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos. Utsumi H, et al. Front Cell Dev Biol, 2024. PMID 38533088, Free PMC Article
    3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase 2A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thrombocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine-protein kinase greatwall
    Names
    microtubule-associated serine/threonine-protein kinase-like
    NP_001003609.2
    XP_021325814.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003609.2 → NP_001003609.2  serine/threonine-protein kinase greatwall

      Status: VALIDATED

      Source sequence(s)
      CT573382
      UniProtKB/Swiss-Prot
      Q6DBX4
      UniProtKB/TrEMBL
      A0A8M1N1C1, F1R778
      Related
      ENSDARP00000072407.4, ENSDART00000077941.5
      Conserved Domains (3) summary
      smart00220
      Location:23 → 185
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05610
      Location:18 → 213
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:630 → 851
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      5893134..5908247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470139.2 → XP_021325814.1  serine/threonine-protein kinase greatwall isoform X1

      UniProtKB/Swiss-Prot
      Q6DBX4
      UniProtKB/TrEMBL
      A0A8M9PLP4
      Conserved Domains (2) summary
      cd05610
      Location:18 → 213
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:630 → 858
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DBX4.1 GenPept UniProtKB/Swiss-Prot:Q6DBX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools