crb1 crumbs cell polarity complex component 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crb1provided by ZNC
Official Full Name: crumbs cell polarity complex component 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-382
See related: Ensembl:ENSDARG00000100506 AllianceGenome:ZFIN:ZDB-GENE-050208-382
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-114d20.6; si:dkey-114d20.7
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within cell projection morphogenesis and establishment or maintenance of epithelial cell apical/basal polarity. Part of protein-containing complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (23489874..23545307, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (23466310..23518743, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish Crb1, Localizing Uniquely to the Cell Membranes around Cone Photoreceptor Axonemes, Alleviates Light Damage to Photoreceptors and Modulates Cones' Light Responsiveness.
Title: Zebrafish Crb1, Localizing Uniquely to the Cell Membranes around Cone Photoreceptor Axonemes, Alleviates Light Damage to Photoreceptors and Modulates Cones' Light Responsiveness.
This study show that the undifferentiated CNS expresses Crb1, Crb2a, and Crb2b in distinct spatial and temporal patterns.
Title: Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development.
Data suggest that the Crb/Moe complex and Notch play roles in a positive feedback loop to maintain the apicobasal polarity in neuroepithelial cells.
Title: Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.
The corneas of zebrafish mutants display severe abnormalities of the epithelial and stromal layers
Title: The role of crumbs genes in the vertebrate cornea.
ome and related crumbs genes are necessary for formation of gross morphological features in several organs, including CNS and renal system; on the cellular level, crumbs genes regulate the formation of both ciliary and nonciliary apical membrane compa
Title: oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: protein crumbs homolog 1

Names: crumbs family member 1, photoreceptor morphogenesis associated; crumbs homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044943.1 → NP_001038408.1 protein crumbs homolog 1 precursor

See identical proteins and their annotated locations for NP_001038408.1

Status: PROVISIONAL

Source sequence(s)

DQ314735

UniProtKB/TrEMBL

Q1A5L3

Related

ENSDARP00000136338.1, ENSDART00000161253.2

Conserved Domains (5) summary

smart00179
Location:413 → 441

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:197 → 232

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:496 → 651

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1151 → 1181

EGF; EGF-like domain

pfam02210
Location:983 → 1113

Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

23489874..23545307 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068216320.1 → XP_068072421.1 protein crumbs homolog 1 isoform X1

Related

ENSDARP00000139259.1, ENSDART00000166915.2

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395107.1 Reference GRCz11 ALT_DRER_TU_1

Range

39252..91445 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001083058.1: Suppressed sequence

Description

NM_001083058.1: This RefSeq was suppressed temporarily by an automatic process because the encoded protein was predicted and was not supported by other sequence data.