foxm1 forkhead box M1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: foxm1provided by ZNC
Official Full Name: forkhead box M1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1275
See related: Ensembl:ENSDARG00000003200 AllianceGenome:ZFIN:ZDB-GENE-040426-1275
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: foxm1l; zgc:63854
Summary: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within cardiac muscle tissue regeneration. Predicted to be active in nucleus. Orthologous to human FOXM1 (forkhead box M1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (5807964..5831537, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (5799394..5822947, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury.
Title: Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury.
foxm1 Modulates Cell Non-Autonomous Response in Zebrafish Skeletal Muscle Homeostasis.
Title: foxm1 Modulates Cell Non-Autonomous Response in Zebrafish Skeletal Muscle Homeostasis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein M1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201097.1 → NP_957391.1 forkhead box protein M1

See identical proteins and their annotated locations for NP_957391.1

Status: PROVISIONAL

Source sequence(s)

BC054560

UniProtKB/TrEMBL

Q7T2G3

Related

ENSDARP00000009248.6, ENSDART00000008898.8

Conserved Domains (1) summary

cd00059
Location:182 → 256

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

5807964..5831537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474973.2 → XP_021330648.1 forkhead box protein M1 isoform X2

UniProtKB/TrEMBL

A0A8M9PUA7

Conserved Domains (1) summary

cd00059
Location:181 → 255

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
XM_068219568.1 → XP_068075669.1 forkhead box protein M1 isoform X4
XM_068219567.1 → XP_068075668.1 forkhead box protein M1 isoform X3
XM_068219566.1 → XP_068075667.1 forkhead box protein M1 isoform X1