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    maco1a macoilin 1a [ Danio rerio (zebrafish) ]

    Gene ID: 393289, updated on 9-Dec-2024

    Summary

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    Official Symbol
    maco1aprovided by ZNC
    Official Full Name
    macoilin 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1097
    See related
    Ensembl:ENSDARG00000005625 AllianceGenome:ZFIN:ZDB-GENE-040426-1097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tmem57; tmem57a; zgc:56620; macoilin-1
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in chemotaxis and neuronal signal transduction. Predicted to be located in endoplasmic reticulum; membrane; and nucleus. Predicted to be active in nuclear membrane and rough endoplasmic reticulum membrane. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See maco1a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (29303847..29333867)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (29716624..29746644)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 3 Neighboring gene serum response factor binding protein 1 Neighboring gene low density lipoprotein receptor adaptor protein 1a Neighboring gene fibronectin type III domain containing 5b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure. Li X, et al. Gene, 2015 Oct 10. PMID 26072164
    2. Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain. Wang S, et al. Front Genet, 2017. PMID 29354154, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56620

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuronal signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in rough endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rough endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    macoilin-1
    Names
    transmembrane protein 57
    transmembrane protein 57a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200319.2 → NP_956613.2  macoilin-1

      See identical proteins and their annotated locations for NP_956613.2

      Status: PROVISIONAL

      Source sequence(s)
      AY845029
      UniProtKB/Swiss-Prot
      Q1L869, Q2TLY0, Q2TLY2
      Related
      ENSDARP00000008156.8, ENSDART00000009149.9
      Conserved Domains (3) summary
      pfam09726
      Location:2 → 662
      Macoilin; Transmembrane protein
      pfam13493
      Location:31 → 114
      DUF4118; Domain of unknown function (DUF4118)
      pfam16331
      Location:386 → 462
      TolA_bind_tri; TolA binding protein trimerization

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      29303847..29333867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2TLY2.1 GenPept UniProtKB/Swiss-Prot:Q2TLY2

    Gene LinkOut

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