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    ftcd formimidoyltransferase cyclodeaminase [ Danio rerio (zebrafish) ]

    Gene ID: 394052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ftcdprovided by ZNC
    Official Full Name
    formimidoyltransferase cyclodeaminaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9643
    See related
    Ensembl:ENSDARG00000007421 AllianceGenome:ZFIN:ZDB-GENE-030131-9643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63647; wu:fp37b11
    Summary
    Predicted to enable folic acid binding activity; formimidoyltetrahydrofolate cyclodeaminase activity; and glutamate formimidoyltransferase activity. Acts upstream of or within hepatocyte homeostasis. Located in Golgi apparatus. Is expressed in liver; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ftcd in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (12770876..12786531)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (12746099..12761754)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene phospholipase C, delta 4a Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene myostatin a Neighboring gene signal transducer and activator of transcription 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of Mg2+ -dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis. Yabu T, et al. J Biol Chem, 2008 Oct 31. PMID 18678863, Free PMC Article
    2. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Zhang C, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31546038
    3. Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. Zhang W, et al. PLoS Genet, 2021 Dec. PMID 34941873, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1.
      Title: Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC63647

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables folic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formimidoyltetrahydrofolate cyclodeaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate formimidoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine catabolic process to glutamate and formamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine catabolic process to glutamate and formate IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-histidine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hepatocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formimidoyltransferase-cyclodeaminase
    Names
    formiminotransferase cyclodeaminase
    NP_957371.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201077.2 → NP_957371.2  formimidoyltransferase-cyclodeaminase

      Status: VALIDATED

      Source sequence(s)
      CF102927, EH487314, EH513708, EH525514
      UniProtKB/TrEMBL
      A0A8M1PIL2
      Related
      ENSDARP00000044682.4, ENSDART00000044683.5
      Conserved Domains (4) summary
      TIGR02024
      Location:1 → 326
      FtcD; glutamate formiminotransferase
      pfam02971
      Location:181 → 324
      FTCD; Formiminotransferase domain
      pfam04961
      Location:339 → 520
      FTCD_C; Formiminotransferase-cyclodeaminase
      pfam07837
      Location:7 → 179
      FTCD_N; Formiminotransferase domain, N-terminal subdomain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      12770876..12786531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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