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    masp2 MBL associated serine protease 2 [ Danio rerio (zebrafish) ]

    Gene ID: 560277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    masp2provided by ZNC
    Official Full Name
    MBL associated serine protease 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060130-154
    See related
    Ensembl:ENSDARG00000007988 AllianceGenome:ZFIN:ZDB-GENE-060130-154
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu714; wu:fb62a09
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within complement activation; innate immune response; and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver. Orthologous to human MASP2 (MBL associated serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See masp2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (28770225..28796159)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (28843684..28869618)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene spermidine synthase Neighboring gene somatostatin family member 7 Neighboring gene DNA fragmentation factor, alpha polypeptide Neighboring gene peroxisomal biogenesis factor 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Li L, et al. Mol Immunol, 2020 Dec. PMID 33160183
    2. Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish. Frohnhöfer HG, et al. Biol Open, 2016 Jun 15. PMID 27215328, Free PMC Article
    3. Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish. Cho HJ, et al. Dis Model Mech, 2019 May 23. PMID 31043432, Free PMC Article
    4. Common responses of fish embryos to metals: an integrated analysis of transcriptomes and methylomes in zebrafish embryos under the stress of copper ions or silver nanoparticles. Tai Z, et al. Metallomics, 2019 Sep 1. PMID 31468037
    5. Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity. Jima DD, et al. Mol Immunol, 2009 Apr. PMID 19200601, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within complement activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannan-binding lectin serine protease 2
    Names
    mannan-binding lectin serine peptidase 2
    NP_001116330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122858.1 → NP_001116330.1  mannan-binding lectin serine protease 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      CR381533
      UniProtKB/TrEMBL
      A0A8M1NGF4
      Related
      ENSDARP00000116209.1, ENSDART00000132179.3
      Conserved Domains (7) summary
      cd00033
      Location:362 → 410
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:435 → 676
      Tryp_SPc; Trypsin-like serine protease
      smart00032
      Location:296 → 357
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00042
      Location:24 → 130
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00179
      Location:134 → 176
      EGF_CA; Calcium-binding EGF-like domain
      cd00190
      Location:436 → 679
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:180 → 289
      CUB; CUB domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      28770225..28796159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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