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    cnot2 CCR4-NOT transcription complex, subunit 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100037372, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cnot2provided by ZNC
    Official Full Name
    CCR4-NOT transcription complex, subunit 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-70
    See related
    Ensembl:ENSDARG00000061802 AllianceGenome:ZFIN:ZDB-GENE-070410-70
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162316
    Summary
    Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening and regulation of stem cell population maintenance. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in telencephalon. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cnot2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (28678888..28713510)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (28235694..28271213)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene formin binding protein 4 Neighboring gene leucine rich repeat containing 10 Neighboring gene WASH complex subunit 4 Neighboring gene solute carrier family 41 member 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Wang D, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17640903, Free PMC Article
    2. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089524.1 → NP_001082993.1  CCR4-NOT transcription complex subunit 2

      See identical proteins and their annotated locations for NP_001082993.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134959
      UniProtKB/TrEMBL
      A0A8M2BA58, A4QN63
      Related
      ENSDARP00000082816.5, ENSDART00000088383.7
      Conserved Domains (1) summary
      pfam04153
      Location:376 → 499
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      28678888..28713510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163111.5 → XP_005163168.1  CCR4-NOT transcription complex subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_005163168.1

      UniProtKB/TrEMBL
      A0A8M2BA58, A4QN63
      Conserved Domains (1) summary
      pfam04153
      Location:376 → 499
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    2. XM_005163109.5 → XP_005163166.1  CCR4-NOT transcription complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA34
      Conserved Domains (1) summary
      pfam04153
      Location:386 → 509
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    3. XM_005163110.5 → XP_005163167.1  CCR4-NOT transcription complex subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_005163167.1

      UniProtKB/TrEMBL
      A0A8M2BA58, A4QN63
      Conserved Domains (1) summary
      pfam04153
      Location:376 → 499
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    4. XM_068217296.1 → XP_068073397.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BA58, A4QN63
    Nucleotide Protein
    Heading Accession and Version

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