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    si:ch73-168d20.1 si:ch73-168d20.1 [ Danio rerio (zebrafish) ]

    Gene ID: 795914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    si:ch73-168d20.1provided by ZNC
    Official Full Name
    si:ch73-168d20.1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121214-44
    See related
    Ensembl:ENSDARG00000039900 AllianceGenome:ZFIN:ZDB-GENE-121214-44
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12) and NLRP5 (NLR family pyrin domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See si:ch73-168d20.1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (45077391..45125490, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (45364071..45412215, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2b Neighboring gene SH3 domain containing GRB2 like 2b, endophilin A1 Neighboring gene zinc finger protein basonuclin-2 Neighboring gene coiled-coil domain containing 171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      45077391..45125490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297169.4 → XP_009295444.1  NACHT, LRR and PYD domains-containing protein 3

      UniProtKB/TrEMBL
      A0A8M3ANC0
      Related
      ENSDARP00000126848.1, ENSDART00000152277.3
      Conserved Domains (6) summary
      smart00368
      Location:879 → 904
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:913 → 1240
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:1143 → 1171
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:853 → 881
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:282 → 447
      NACHT; NACHT domain
      pfam14484
      Location:203 → 271
      FISNA; Fish-specific NACHT associated domain
    Nucleotide Protein
    Heading Accession and Version

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