barhl2 BarH-like homeobox 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: barhl2provided by ZNC
Official Full Name: BarH-like homeobox 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-153
See related: Ensembl:ENSDARG00000104361 AllianceGenome:ZFIN:ZDB-GENE-050913-153
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: B-H2; wu:fq39g04; zgc:113948
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BARHL2 (BarH like homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (24817852..24821681)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (24718043..24721872)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Barhl2 is an amacrine-cell subtype identity-biasing factor that turns on within Atoh7-positive descendants.
Title: Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: barH-like 2 homeobox protein

Names: BarH-like 2; barH-class homeodomain transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205740.1 → NP_991303.1 barH-like 2 homeobox protein

See identical proteins and their annotated locations for NP_991303.1

Status: PROVISIONAL

Source sequence(s)

AY145141

UniProtKB/TrEMBL

A0A8M1PKA0, Q6YI96

Related

ENSDARP00000137279.1, ENSDART00000165609.2

Conserved Domains (2) summary

COG5576
Location:190 → 299

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:213 → 265

Homeobox; Homeobox domain