elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: elmo1provided by ZNC
Official Full Name: engulfment and cell motility 1 (ced-12 homolog, C. elegans)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2069
See related: Ensembl:ENSDARG00000098753 AllianceGenome:ZFIN:ZDB-GENE-040426-2069
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:85612; im:7151147; wu:fq24e08
Summary: Predicted to enable SH3 domain binding activity. Acts upstream of or within cilium assembly; lymphangiogenesis; and positive regulation of angiogenesis. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood vessel; immature eye; mesoderm; nervous system; and pronephric tubule. Orthologous to human ELMO1 (engulfment and cell motility 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (33887589..34063490, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (34300469..34476382, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elmo1 is expressed in the developing nervous system. Elmo1 regulates axonal wrapping in the Posterior Lateral Line nerve.
Title: Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish.
these results highlight ELMO1 as an important factor for glomerular protection and renal cell survival via decreasing apoptosis, especially under diabetic conditions.
Title: ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions.
ELMO-DOCK1, a bipartite guanine nucleotide exchange factor complex for the small GTPase Rac1, and for the membrane-cytoskeletal linker Ezrin, regulates centriole/basal body migration, docking and spacing.
Title: The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin.
A novel signaling cascade is identified in which ELMO1/DOCK180 regulates vasculature formation in zebrafish.
Title: The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of guanyl-nucleotide exchange factor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: engulfment and cell motility protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213091.1 → NP_998256.1 engulfment and cell motility protein 1

See identical proteins and their annotated locations for NP_998256.1

Status: PROVISIONAL

Source sequence(s)

BC068327

UniProtKB/TrEMBL

A0A8M3AL10, Q6NV39

Related

ENSDARP00000132398.1, ENSDART00000172618.2

Conserved Domains (3) summary

cd13359
Location:545 → 674

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:305 → 475

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:115 → 279

DUF3361; Domain of unknown function (DUF3361)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

33887589..34063490 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009294313.4 → XP_009292588.1 engulfment and cell motility protein 1 isoform X4

UniProtKB/TrEMBL

A0A8M3ASM6

Conserved Domains (3) summary

cd13359
Location:533 → 662

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:293 → 463

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:115 → 267

DUF3361; Domain of unknown function (DUF3361)
XM_009294310.4 → XP_009292585.1 engulfment and cell motility protein 1 isoform X2

UniProtKB/TrEMBL

A0A2R8RS12, A0A8M3B3L5

Related

ENSDARP00000151585.1, ENSDART00000183907.1

Conserved Domains (3) summary

cd13359
Location:547 → 676

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:307 → 477

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:115 → 281

DUF3361; Domain of unknown function (DUF3361)
XM_009294311.4 → XP_009292586.1 engulfment and cell motility protein 1 isoform X3

See identical proteins and their annotated locations for XP_009292586.1

UniProtKB/TrEMBL

A0A8M3AL10, Q6NV39

Conserved Domains (3) summary

cd13359
Location:545 → 674

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:305 → 475

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:115 → 279

DUF3361; Domain of unknown function (DUF3361)
XM_009294308.4 → XP_009292583.1 engulfment and cell motility protein 1 isoform X1

See identical proteins and their annotated locations for XP_009292583.1

UniProtKB/TrEMBL

A0A0R4IHP8, A0A8M3ASM3

Related

ENSDARP00000132947.1, ENSDART00000157815.2

Conserved Domains (3) summary

cd13359
Location:559 → 688

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:319 → 489

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:115 → 293

DUF3361; Domain of unknown function (DUF3361)
XM_068215107.1 → XP_068071208.1 engulfment and cell motility protein 1 isoform X3

UniProtKB/TrEMBL

A0A8M3AL10, Q6NV39
XM_068215106.1 → XP_068071207.1 engulfment and cell motility protein 1 isoform X1

UniProtKB/TrEMBL

A0A0R4IHP8, A0A8M3ASM3
XM_009294309.4 → XP_009292584.1 engulfment and cell motility protein 1 isoform X1

See identical proteins and their annotated locations for XP_009292584.1

UniProtKB/TrEMBL

A0A0R4IHP8, A0A8M3ASM3

Conserved Domains (3) summary

cd13359
Location:559 → 688

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:319 → 489

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:115 → 293

DUF3361; Domain of unknown function (DUF3361)
XM_009294312.4 → XP_009292587.1 engulfment and cell motility protein 1 isoform X5

UniProtKB/TrEMBL

A0A8M3AVM1

Conserved Domains (1) summary

cd13359
Location:66 → 195

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain