celf4 CUGBP, Elav-like family member 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: celf4provided by ZNC
Official Full Name: CUGBP, Elav-like family member 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-300
See related: Ensembl:ENSDARG00000070045 AllianceGenome:ZFIN:ZDB-GENE-040718-300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CELF-4; brunol4; zgc:92761
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition; positive regulation of mRNA splicing, via spliceosome; and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CELF4 (CUGBP Elav-like family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (12076688..12332751, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (11984060..12180027, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CUGBP Elav-like family member 4

Names: CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4; bruno-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002562.2 → NP_001002562.1 CUGBP Elav-like family member 4

See identical proteins and their annotated locations for NP_001002562.1

Status: VALIDATED

Source sequence(s)

CR388214, CU914484, EH585011, EH602446

UniProtKB/Swiss-Prot

Q6DGV1

Related

ENSDARP00000075951.6, ENSDART00000081510.6

Conserved Domains (4) summary

cd12639
Location:431 → 509

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

TIGR01642
Location:298 → 509

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:134 → 214

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

12076688..12332751 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068215836.1 → XP_068071937.1 CUGBP Elav-like family member 4 isoform X9

Related

ENSDARP00000122295.1, ENSDART00000131538.3
XM_068215835.1 → XP_068071936.1 CUGBP Elav-like family member 4 isoform X9
XM_068215834.1 → XP_068071935.1 CUGBP Elav-like family member 4 isoform X9
XM_068215837.1 → XP_068071938.1 CUGBP Elav-like family member 4 isoform X11
XM_021468808.2 → XP_021324483.1 CUGBP Elav-like family member 4 isoform X10

UniProtKB/TrEMBL

A0A8M9PCL3

Conserved Domains (4) summary

TIGR01628
Location:49 → 371

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:394 → 472

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:133 → 213

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_009295193.4 → XP_009293468.1 CUGBP Elav-like family member 4 isoform X3

UniProtKB/TrEMBL

A0A8M3ALA7

Conserved Domains (4) summary

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:133 → 213

RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12639
Location:451 → 529

RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

TIGR01661
Location:49 → 540

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_021468806.2 → XP_021324481.1 CUGBP Elav-like family member 4 isoform X7

UniProtKB/TrEMBL

A0A8M9PQD3

Conserved Domains (4) summary

TIGR01628
Location:49 → 378

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:394 → 472

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:134 → 214

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_021468807.2 → XP_021324482.1 CUGBP Elav-like family member 4 isoform X8

UniProtKB/TrEMBL

A0A8M9P396

Conserved Domains (4) summary

TIGR01628
Location:49 → 372

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:134 → 214

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cl17169
Location:393 → 463

RRM_SF; RNA recognition motif (RRM) superfamily
XM_021468805.2 → XP_021324480.1 CUGBP Elav-like family member 4 isoform X6

UniProtKB/TrEMBL

A0A8M9PTS7

Conserved Domains (4) summary

TIGR01628
Location:49 → 372

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:395 → 473

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:134 → 214

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_017352768.3 → XP_017208257.1 CUGBP Elav-like family member 4 isoform X4

UniProtKB/TrEMBL

A0A8M6Z3M4

Conserved Domains (4) summary

cd12639
Location:432 → 510

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

TIGR01642
Location:281 → 510

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:134 → 214

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_009295192.4 → XP_009293467.1 CUGBP Elav-like family member 4 isoform X2

UniProtKB/TrEMBL

A0A8M3ATP3

Conserved Domains (4) summary

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:134 → 214

RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12639
Location:451 → 529

RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

TIGR01661
Location:49 → 536

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_009295194.4 → XP_009293469.1 CUGBP Elav-like family member 4 isoform X5

UniProtKB/TrEMBL

A0A8M3B4J4

Conserved Domains (3) summary

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:134 → 214

RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cl17169
Location:450 → 520

RRM_SF; RNA recognition motif (RRM) superfamily
XM_009295191.4 → XP_009293466.1 CUGBP Elav-like family member 4 isoform X1

UniProtKB/TrEMBL

A0A8M3AWN6

Conserved Domains (4) summary

cd12632
Location:42 → 128

RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:134 → 214

RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12639
Location:452 → 530

RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

TIGR01661
Location:49 → 537

ELAV_HUD_SF; ELAV/HuD family splicing factor