flvcr2b FLVCR choline and putative heme transporter 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: flvcr2bprovided by ZNC
Official Full Name: FLVCR choline and putative heme transporter 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-312
See related: Ensembl:ENSDARG00000031506 AllianceGenome:ZFIN:ZDB-GENE-041210-312
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc07b07; wu:fc07b07; si:ch211-119b12.6
Summary: Predicted to enable ethanolamine transmembrane transporter activity; heme binding activity; and heme transmembrane transporter activity. Predicted to be involved in heme export and transport across blood-brain barrier. Predicted to act upstream of or within transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (46311440..46349064)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (46407412..46445332)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc07b07.x1 (e-PCR)
- UniSTS:187713

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ethanolamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme export	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transport across blood-brain barrier	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: choline/ethanolamine transporter flvcr2b; heme transporter FLVCR2

Names: FLVCR heme transporter 2b; feline leukemia virus subgroup C cellular receptor family, member 2b; feline leukemia virus subgroup C receptor-related protein 2 homolog B; flvsr2a; heme transporter flvcr2b; major facilitator superfamily domain containing 7C-b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

46311440..46349064

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003200755.6 → XP_003200803.1 heme transporter FLVCR2 isoform X1

UniProtKB/TrEMBL

A0AAR9KR84

Related

ENSDARP00000038667.5, ENSDART00000038696.8

Conserved Domains (2) summary

cd06174
Location:60 → 458

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:60 → 424

MFS_1; Major Facilitator Superfamily
XM_005160868.5 → XP_005160925.1 heme transporter FLVCR2 isoform X2

UniProtKB/TrEMBL

A0AAR9Y6Z6

Related

ENSDARP00000145286.1, ENSDART00000184743.1

Conserved Domains (2) summary

cd06174
Location:60 → 458

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:60 → 424

MFS_1; Major Facilitator Superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395077.1 Reference GRCz11 ALT_DRER_TU_1

Range

47883..81755

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021473380.2 → XP_021329055.1 heme transporter FLVCR2 isoform X1

UniProtKB/TrEMBL

A0AAS8BI50

Conserved Domains (1) summary

cd06174
Location:60 → 458

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
XM_021473381.2 → XP_021329056.1 heme transporter FLVCR2 isoform X2

UniProtKB/Swiss-Prot

A0A8M1RMV1, A0A8M2B829, A0A8M9Q308, A0A8M9Q757, E9QH04

Conserved Domains (1) summary

cd06174
Location:60 → 458

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...