acsl4a acyl-CoA synthetase long chain family member 4a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acsl4aprovided by ZNC
Official Full Name: acyl-CoA synthetase long chain family member 4aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1565
See related: Ensembl:ENSDARG00000004078 AllianceGenome:ZFIN:ZDB-GENE-040426-1565
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: acsl4; zgc:66186
Summary: Predicted to enable arachidonate-CoA ligase activity. Acts upstream of or within dorsal/ventral pattern formation and regulation of signal transduction. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; heart; nervous system; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (28438947..28459446)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (28132989..28153488)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd58g12.y1 (e-PCR)
- UniSTS:195731

fd20e05.x1 (e-PCR)
- UniSTS:204277

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables arachidonate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty-acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: long-chain-fatty-acid--CoA ligase 4

Names: acsl4b; acyl-CoA synthetase long-chain family member 4

NP_956943.1

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200649.1 → NP_956943.1 long-chain-fatty-acid--CoA ligase 4

See identical proteins and their annotated locations for NP_956943.1

Status: PROVISIONAL

Source sequence(s)

BC057476

UniProtKB/TrEMBL

Q6PFP1

Related

ENSDARP00000010373.6, ENSDART00000006489.8

Conserved Domains (2) summary

cd05927
Location:117 → 703

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

PLN02387
Location:60 → 703

PLN02387; long-chain-fatty-acid-CoA ligase family protein