f13a1b coagulation factor XIII, A1 polypeptide b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: f13a1bprovided by ZNC
Official Full Name: coagulation factor XIII, A1 polypeptide bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9634
See related: Ensembl:ENSDARG00000036893 AllianceGenome:ZFIN:ZDB-GENE-030131-9634
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: f13a1; fo83d04; wu:fo83d04; zgc:153334
Summary: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in blood coagulation, fibrin clot formation. Predicted to act upstream of or within peptide cross-linking. Is expressed in pectoral fin and retina. Human ortholog(s) of this gene implicated in artery disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Orthologous to human F13A1 (coagulation factor XIII A chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (8270774..8315179, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (8024816..8069221, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel activation mechanism of FXIII-A in the zebrafish retina after optic nerve injury is presented. FXIII-A mRNA and protein are shortened after optic nerve injury. Heat shock factor-1 produces of an active form of short FXIII-A mRNA.
Title: A novel activation mechanism of cellular Factor XIII in zebrafish retina after optic nerve injury.
In the injured optic nerve, mRNA expression of FXIII-A from the region encoding the activation peptide was markedly suppressed compared with the region encoding the active site. Alternative splicing may occur in the FXIII-A gene, resulting in deletion of the region encoding the activation peptide, allowing direct production of activated FXIII-A protein in the fish retina and injured optic nerve.
Title: Alternative Splicing for Activation of Coagulation Factor XIII-A in the Fish Retina After Optic Nerve Injury.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation, fibrin clot formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptide cross-linking	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: coagulation factor XIII A chain

Names: FX111a-87

NP_001070622.1

EC 2.3.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077154.1 → NP_001070622.1 coagulation factor XIII A chain

See identical proteins and their annotated locations for NP_001070622.1

Status: PROVISIONAL

Source sequence(s)

BC124320

UniProtKB/TrEMBL

A0A8M9QC25, Q08CA3

Related

ENSDARP00000147730.1, ENSDART00000184049.1

Conserved Domains (3) summary

smart00460
Location:327 → 418

TGc; Transglutaminase/protease-like homologues

pfam00868
Location:65 → 179

Transglut_N; Transglutaminase family

pfam00927
Location:645 → 741

Transglut_C; Transglutaminase family, C-terminal ig like domain