inhbaa inhibin subunit beta Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: inhbaaprovided by ZNC
Official Full Name: inhibin subunit beta Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000210-21
See related: Ensembl:ENSDARG00000012671 AllianceGenome:ZFIN:ZDB-GENE-000210-21
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: actba; inhba; fk40h12; inhbaa-001; wu:fk40h12
Summary: Predicted to enable cytokine activity. Acts upstream of or within with a positive effect on cardiac muscle myoblast proliferation. Acts upstream of or within fin regeneration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including anterior axial hypoblast; gonad; hatching gland; polster; and trigeminal ganglion. Orthologous to human INHBA (inhibin subunit beta A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (3049646..3061966)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (3191762..3203890, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhbaa functions as a cardiomyocyte mitogen and that its overexpression leads to accelerated cardiac recovery and scar clearance after injury.
Title: Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair.
The present study demonstrated that EGF controlled expression of three activin subunits (inhbaa, inhbab and inhbb) in the follicle cells via diverse signaling pathways.
Title: Epidermal growth factor differentially regulates activin subunits in the zebrafish ovarian follicle cells via diverse signaling pathways.
Activin betaA is involved in promoting ovary and follicle growth, whereas activin betaB may have a tonic role throughout follicle development but becomes critical at the late stage of oocyte maturation and/or ovulation.
Title: Developmental profiles of activin betaA, betaB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle.
the hCG-stimulated activin betaA expression is dependent on the activation of the cAMP-PKA pathway
Title: Involvement of cyclic adenosine 3',5'-monophosphate in the differential regulation of activin betaA and betaB expression by gonadotropin in the zebrafish ovarian follicle cells.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect cardiac muscle myoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inhibin subunit beta Aa

Names: activin beta A; activin beta A1; inhibin, beta Aa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362254.1 → NP_001349183.1 inhibin subunit beta Aa

Status: VALIDATED

Source sequence(s)

CR931801

UniProtKB/TrEMBL

F6NX96, Q6NYZ8, Q8QGE3

Conserved Domains (2) summary

pfam00019
Location:290 → 394

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:67 → 263

TGFb_propeptide; TGF-beta propeptide
NM_130916.1 → NP_570991.1 inhibin subunit beta Aa

See identical proteins and their annotated locations for NP_570991.1

Status: PROVISIONAL

Source sequence(s)

BC066402

UniProtKB/TrEMBL

F6NX96, Q6NYZ8, Q8QGE3

Related

ENSDARP00000006400.7, ENSDART00000004241.8

Conserved Domains (2) summary

pfam00019
Location:290 → 394

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:67 → 263

TGFb_propeptide; TGF-beta propeptide