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    ppp3cca protein phosphatase 3, catalytic subunit, gamma isozyme, a [ Danio rerio (zebrafish) ]

    Gene ID: 557926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp3ccaprovided by ZNC
    Official Full Name
    protein phosphatase 3, catalytic subunit, gamma isozyme, aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030829-36
    See related
    Ensembl:ENSDARG00000014962 AllianceGenome:ZFIN:ZDB-GENE-030829-36
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ppp3cc; sb:cb767; si:dkey-21k4.5
    Summary
    Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including hatching gland; musculature system; nervous system; polster; and trigeminal placode. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppp3cca in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (27924330..27994672, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (27323003..27394550, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transcriptional and immune response regulator a Neighboring gene ADAM metallopeptidase domain 28 Neighboring gene VPS37B subunit of ESCRT-I a Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A radiation hybrid map of the zebrafish genome. Geisler R, et al. Nat Genet, 1999 Sep. PMID 10471505
    2. Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Sojan JM, et al. Front Nutr, 2022. PMID 35571926, Free PMC Article
    3. Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Cao S, et al. Zebrafish, 2023 Feb. PMID 36795618, Free PMC Article
    4. Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Lu Y, et al. Front Mol Neurosci, 2022. PMID 35600071, Free PMC Article
    5. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 3, catalytic subunit, gamma isozyme, a
    NP_001160100.1
    XP_005171933.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166628.1 → NP_001160100.1  protein phosphatase 3, catalytic subunit, gamma isozyme, a

      Status: VALIDATED

      Source sequence(s)
      AL929297, BX666060, CN326680, EH436386, EH461939, EH548361
      UniProtKB/TrEMBL
      A0A8M1NSY8, A3KGZ6
      Related
      ENSDARP00000121481.1, ENSDART00000132740.3
      Conserved Domains (2) summary
      smart00156
      Location:59 → 327
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:39 → 343
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      27924330..27994672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171876.5 → XP_005171933.1  protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1

      UniProtKB/TrEMBL
      A0A286YA34, A0A8M2BJ63
      Related
      ENSDARP00000144033.2, ENSDART00000175819.2
      Conserved Domains (2) summary
      smart00156
      Location:59 → 327
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:39 → 343
      MPP_PP2B; PP2B, metallophosphatase domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394577.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      392857..413381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395236.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      162198..234198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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