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    eif2ak3 eukaryotic translation initiation factor 2-alpha kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 559564, updated on 15-Dec-2024

    Summary

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    Official Symbol
    eif2ak3provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2-alpha kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050414-2
    See related
    Ensembl:ENSDARG00000062139 AllianceGenome:ZFIN:ZDB-GENE-050414-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    PEK; zgc:152949
    Summary
    Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Acts upstream of or within response to endoplasmic reticulum stress and response to hypoxia. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; liver; and male organism. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eif2ak3 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (13945216..14004550)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (13814162..13873558)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 11 Neighboring gene uncharacterized LOC137487374 Neighboring gene ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase) Neighboring gene uncharacterized LOC101884819 Neighboring gene attractin Neighboring gene GDNF family receptor alpha 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains. Rothenburg S, et al. Proc Natl Acad Sci U S A, 2005 Feb 1. PMID 15659550, Free PMC Article
    2. Loss of Gspt1l disturbs the patterning of the brain central arteries in zebrafish. Wang H, et al. Biochem Biophys Res Commun, 2017 Apr 22. PMID 28285134
    3. A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis. Liu ZY, et al. Gene, 2013 Sep 15. PMID 23742890
    4. Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish. Mukaigasa K, et al. Proc Natl Acad Sci U S A, 2018 Mar 13. PMID 29472449, Free PMC Article
    5. Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Xin S, et al. Mar Drugs, 2024 Mar 27. PMID 38667765, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152949

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2-alpha kinase 3
    Names
    PERK
    XP_005156642.2
    XP_021336441.1
    XP_068069115.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      13945216..14004550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213014.1 → XP_068069115.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X2

    2. XM_021480766.2 → XP_021336441.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QK34, B8JI14
      Related
      ENSDARP00000120826.1, ENSDART00000142997.2
      Conserved Domains (2) summary
      cd09768
      Location:100 → 437
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      cd14048
      Location:606 → 1063
      STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394873.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      179275..234501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156585.5 → XP_005156642.2  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3B8
      Conserved Domains (2) summary
      cd09768
      Location:100 → 437
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      cd14048
      Location:606 → 1063
      STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077149.2: Suppressed sequence

      Description
      NM_001077149.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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