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    eri1 exoribonuclease 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eri1provided by ZNC
    Official Full Name
    exoribonuclease 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-39
    See related
    Ensembl:ENSDARG00000044692 AllianceGenome:ZFIN:ZDB-GENE-050522-39
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    thex1; zgc:110635
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within regulatory ncRNA-mediated gene silencing. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ERI1 (exoribonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eri1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (19907763..19915900, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (19871125..19879264, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene FYN binding protein 1 b Neighboring gene multifunctional ROCO family signaling regulator 1 Neighboring gene protein phosphatase 1, regulatory subunit 3B Neighboring gene tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Treatment with small interfering RNA affects the microRNA pathway and causes unspecific defects in zebrafish embryos. Zhao XF, et al. FEBS J, 2008 May. PMID 18384379
    2. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Kennedy S, et al. Nature, 2004 Feb 12. PMID 14961122
    3. NEFLb impairs early nervous system development via regulation of neuron apoptosis in zebrafish. Wang S, et al. J Cell Physiol, 2019 Jul. PMID 30569449
    4. Functional analysis of human hematopoietic stem cell gene expression using zebrafish. Eckfeldt CE, et al. PLoS Biol, 2005 Aug. PMID 16089502, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110635

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3'-5' exoribonuclease 1
    Names
    three prime histone mRNA exonuclease 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020614.1 → NP_001018450.1  3'-5' exoribonuclease 1

      See identical proteins and their annotated locations for NP_001018450.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095343
      UniProtKB/TrEMBL
      A0A2R8QDC1, F6NW04, Q503G0
      Related
      ENSDARP00000065670.5, ENSDART00000065671.7
      Conserved Domains (2) summary
      cd06133
      Location:118 → 298
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
      pfam02037
      Location:62 → 96
      SAP; SAP domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      19907763..19915900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215870.1 → XP_068071971.1  3'-5' exoribonuclease 1 isoform X1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395088.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      36368..44505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395348.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      36501..44540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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