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    sgtb small glutamine rich tetratricopeptide repeat co-chaperone beta [ Danio rerio (zebrafish) ]

    Gene ID: 431772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sgtbprovided by ZNC
    Official Full Name
    small glutamine rich tetratricopeptide repeat co-chaperone betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040704-72
    See related
    Ensembl:ENSDARG00000016769 AllianceGenome:ZFIN:ZDB-GENE-040704-72
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92462
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be part of TRC complex. Predicted to be active in membrane. Orthologous to human SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sgtb in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (15381972..15405564, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (15423853..15447447, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily V, member 2a Neighboring gene pumilio RNA-binding family member 3 Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene neurolysin (metallopeptidase M3 family) Neighboring gene erbb2 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TRC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small glutamine-rich tetratricopeptide repeat-containing protein beta
    Names
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002225.2 → NP_001002225.2  small glutamine-rich tetratricopeptide repeat-containing protein beta

      Status: VALIDATED

      Source sequence(s)
      CR925725, EH435811, EH446588, EH461811, EH472441
      UniProtKB/TrEMBL
      A0A8M1N099, F1R7L2
      Related
      ENSDARP00000013325.9, ENSDART00000020665.11
      Conserved Domains (5) summary
      smart00028
      Location:101 → 134
      TPR; Tetratricopeptide repeats
      sd00006
      Location:101 → 129
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:169 → 202
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:100 → 166
      TPR_11; TPR repeat
      pfam16546
      Location:20 → 76
      SGTA_dimer; Homodimerization domain of SGTA

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      15381972..15405564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305189.2 → XP_009303464.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X1

      UniProtKB/TrEMBL
      A0A8M3AWM6
      Conserved Domains (5) summary
      smart00028
      Location:101 → 134
      TPR; Tetratricopeptide repeats
      sd00006
      Location:101 → 129
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:169 → 202
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:100 → 166
      TPR_11; TPR repeat
      pfam16546
      Location:20 → 76
      SGTA_dimer; Homodimerization domain of SGTA
    Nucleotide Protein Strain
    Heading Accession and Version

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