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    znf451 zinc finger protein 451 [ Danio rerio (zebrafish) ]

    Gene ID: 557758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    znf451provided by ZNC
    Official Full Name
    zinc finger protein 451provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081107-14
    See related
    Ensembl:ENSDARG00000076939 AllianceGenome:ZFIN:ZDB-GENE-081107-14
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-165e15.5
    Summary
    Predicted to enable ligase activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF451 (zinc finger protein 451). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See znf451 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (1409781..1427255, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (1279495..1297003, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene RAB23, member RAS oncogene family Neighboring gene BCL2 associated athanogene 2 Neighboring gene dystonin Neighboring gene uncharacterized LOC137487351 Neighboring gene zmp:0000000760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of bovine A20 gene: Expression mediated by NF-κB pathway in MDBK cells infected with bovine viral diarrhea virus-1. Fredericksen F, et al. Gene, 2016 May 1. PMID 26809100
    2. Melanoma genome evolution across species. Kansler ER, et al. BMC Genomics, 2017 Feb 7. PMID 28173755, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase ZNF451; zinc finger protein 451

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      1409781..1427255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358909.3 → XP_017214398.1  E3 SUMO-protein ligase ZNF451 isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z1V8, A0A8M9PY94

    2. XM_001923135.7 → XP_001923170.1  E3 SUMO-protein ligase ZNF451 isoform X1

      See identical proteins and their annotated locations for XP_001923170.1

      UniProtKB/TrEMBL
      A0A8M1QHV0, A0A8M9PY94, B8A455
      Related
      ENSDARP00000120051.1, ENSDART00000145867.3
      Conserved Domains (2) summary
      pfam12756
      Location:188 → 252
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      cl26511
      Location:759 → 915
      Neuromodulin_N; Gap junction protein N-terminal region

    RNA

    1. XR_011005870.1 RNA Sequence

    2. XR_222069.5 RNA Sequence

    3. XR_011005872.1 RNA Sequence

    4. XR_011005871.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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