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    cox7b cytochrome c oxidase subunit 7B [ Danio rerio (zebrafish) ]

    Gene ID: 563476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cox7bprovided by ZNC
    Official Full Name
    cytochrome c oxidase subunit 7Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6602
    See related
    Ensembl:ENSDARG00000115557 AllianceGenome:ZFIN:ZDB-GENE-030131-6602
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk47c09; wu:fk47c09; zgc:194876
    Summary
    Predicted to act upstream of or within mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Is expressed in brain and gill. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 2. Orthologous to human COX7B (cytochrome c oxidase subunit 7B) and COX7B2 (cytochrome c oxidase subunit 7B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cox7b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (37443003..37444155)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (37757816..37758968)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene progesterone receptor membrane component 1 Neighboring gene transfer RNA leucine (anticodon CAA) Neighboring gene phosphoglycerate kinase 1 Neighboring gene angiomotin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Coordination of cytochrome c oxidase gene expression in the remodelling of skeletal muscle. Duggan AT, et al. J Exp Biol, 2011 Jun 1. PMID 21562175
    2. Evolution of the nuclear-encoded cytochrome oxidase subunits in vertebrates. Little AG, et al. Physiol Genomics, 2010 Jun. PMID 20233836
    3. asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. Cai W, et al. Int J Mol Sci, 2023 Nov 15. PMID 38003559, Free PMC Article
    4. Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model. Li Y, et al. Dis Model Mech, 2019 Oct 17. PMID 31515263, Free PMC Article
    5. Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Chen M, et al. Front Immunol, 2019. PMID 31787979, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 7B, mitochondrial
    Names
    cytochrome c oxidase subunit VIIb
    NP_001124074.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130602.1 → NP_001124074.1  cytochrome c oxidase subunit 7B, mitochondrial

      See identical proteins and their annotated locations for NP_001124074.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163420
      UniProtKB/TrEMBL
      B3DJA6, B3DJB1
      Related
      ENSDARP00000154083.1, ENSDART00000186950.1
      Conserved Domains (1) summary
      pfam05392
      Location:35 → 111
      COX7B; Cytochrome C oxidase chain VIIB

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      37443003..37444155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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