phkg2 phosphorylase kinase, gamma 2 (testis) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: phkg2provided by ZNC
Official Full Name: phosphorylase kinase, gamma 2 (testis)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-825
See related: Ensembl:ENSDARG00000054208 AllianceGenome:ZFIN:ZDB-GENE-040426-825
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55863
Summary: Predicted to enable phosphorylase kinase activity. Predicted to be involved in glycogen metabolic process and signal transduction. Predicted to act upstream of or within glycogen biosynthetic process and protein phosphorylation. Predicted to be part of phosphorylase kinase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to human PHKG2 (phosphorylase kinase catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (28888975..28901184)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (28774073..28786282)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphorylase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorylase kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphorylase kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphorylase kinase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphorylase b kinase gamma catalytic chain, liver/testis isoform

NP_957256.1

EC 2.7.11.19

XP_009304874.1

EC 2.7.11.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200962.1 → NP_957256.1 phosphorylase b kinase gamma catalytic chain, liver/testis isoform

See identical proteins and their annotated locations for NP_957256.1

Status: PROVISIONAL

Source sequence(s)

BC047191

UniProtKB/TrEMBL

Q7ZYW8

Related

ENSDARP00000070836.3, ENSDART00000076362.4

Conserved Domains (2) summary

cd14181
Location:13 → 291

STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

pfam00069
Location:24 → 291

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

28888975..28901184

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009306599.4 → XP_009304874.1 phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

UniProtKB/TrEMBL

A0A8M3AY76, F1QXS6

Conserved Domains (2) summary

pfam00069
Location:24 → 291

Pkinase; Protein kinase domain

cl21453
Location:13 → 291

PKc_like; Protein Kinases, catalytic domain