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    syt4 synaptotagmin IV [ Danio rerio (zebrafish) ]

    Gene ID: 335357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    syt4provided by ZNC
    Official Full Name
    synaptotagmin IVprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7297
    See related
    Ensembl:ENSDARG00000036505 AllianceGenome:ZFIN:ZDB-GENE-030131-7297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73240; wu:fj05d11
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and vesicle fusion. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; exocytic vesicle; and synapse. Is expressed in nervous system and neural tube. Orthologous to human SYT4 (synaptotagmin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See syt4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (23907746..23916118)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (23636589..23644961)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene von Hippel-Lindau binding protein 1 Neighboring gene uncharacterized LOC101883418 Neighboring gene si:dkey-183c6.7 Neighboring gene si:dkey-183c6.8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rest represses maturation within migrating facial branchiomotor neurons. Love CE, et al. Dev Biol, 2015 May 15. PMID 25769695, Free PMC Article
    2. Expression and distribution of synaptotagmin family members in the zebrafish retina. Henry D, et al. J Comp Neurol, 2022 Mar. PMID 34468021, Free PMC Article
    3. Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b. Moravec CE, et al. J Neurosci, 2016 Sep 7. PMID 27605615, Free PMC Article
    4. CoRest1 regulates neurogenesis in a stage-dependent manner. Monestime CM, et al. Dev Dyn, 2019 Oct. PMID 31301200, Free PMC Article
    5. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. Craxton M. BMC Genomics, 2007 Jul 31. PMID 17672888, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199948.1 → NP_956242.1  synaptotagmin-4

      See identical proteins and their annotated locations for NP_956242.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059580
      UniProtKB/TrEMBL
      A0A8M1PDQ6, Q6PBU6
      Related
      ENSDARP00000045478.6, ENSDART00000045479.7
      Conserved Domains (2) summary
      cd08388
      Location:166 → 292
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:301 → 437
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      23907746..23916118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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