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    actr10 actin related protein 10 [ Danio rerio (zebrafish) ]

    Gene ID: 393139, updated on 4-Jan-2025

    Summary

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    Official Symbol
    actr10provided by ZNC
    Official Full Name
    actin related protein 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-768
    See related
    Ensembl:ENSDARG00000038432 AllianceGenome:ZFIN:ZDB-GENE-040426-768
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55635
    Summary
    Acts upstream of or within central nervous system myelin formation and retrograde axonal transport of mitochondrion. Predicted to be part of dynactin complex. Is expressed in brain and posterior lateral line ganglion. Orthologous to human ACTR10 (actin related protein 10). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See actr10 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (54274431..54286860)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54404860..54417289)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene PRP39 pre-mRNA processing factor 39 homolog (yeast) Neighboring gene FKBP prolyl isomerase 3 Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 2 Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Retrograde Mitochondrial Transport Is Essential for Organelle Distribution and Health in Zebrafish Neurons. Mandal A, et al. J Neurosci, 2021 Feb 17. PMID 33376159, Free PMC Article
    2. Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo. Herbert AL, et al. Proc Natl Acad Sci U S A, 2017 Oct 24. PMID 29073112, Free PMC Article
    3. Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. Drerup CM, et al. Elife, 2017 Apr 17. PMID 28414272, Free PMC Article
    4. Noncanonical and canonical splice sites: a novel mutation at the rare noncanonical splice-donor cut site (IVS4+1A>G) of SEDL causes variable splicing isoforms in X-linked spondyloepiphyseal dysplasia tarda. Xiong F, et al. Eur J Hum Genet, 2009 Apr. PMID 19002213, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Actr10 role in MBP mRNA localization in oligodendrocytes.
      Title: Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.
    2. Together, this work identifies Actr10 as a factor necessary for dynactin-mitochondria interaction, enhancing our understanding of how mitochondria properly localize in axons.
      Title: Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55635

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system myelin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retrograde axonal transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 10
    Names
    ARP10 actin related protein 10 homolog
    actin-related protein 10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200170.1 → NP_956464.1  actin-related protein 10

      See identical proteins and their annotated locations for NP_956464.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045412
      UniProtKB/TrEMBL
      Q7ZVU0
      Related
      ENSDARP00000090111.3, ENSDART00000099338.6
      Conserved Domains (2) summary
      smart00268
      Location:13 → 362
      ACTIN; Actin
      cl17037
      Location:12 → 362
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      54274431..54286860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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