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    pleca plectin a [ Danio rerio (zebrafish) ]

    Gene ID: 567639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plecaprovided by ZNC
    Official Full Name
    plectin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8984
    See related
    Ensembl:ENSDARG00000062590 AllianceGenome:ZFIN:ZDB-GENE-030131-8984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa95h11; sb:eu420; plec1-like; wu:fa95h11; si:dkey-151c10.1
    Summary
    Predicted to enable ankyrin binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within locomotory behavior and skeletal muscle tissue development. Predicted to be located in cytoskeleton and membrane. Predicted to be active in several cellular components, including focal adhesion; hemidesmosome; and sarcolemma. Predicted to colocalize with intermediate filament. Is expressed in epidermis; telencephalon; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Q; epidermolysis bullosa simplex; epidermolysis bullosa simplex Ogna type; and epidermolysis bullosa simplex with muscular dystrophy. Orthologous to human PLEC (plectin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pleca in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (22408308..22621646, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (22823985..22894565, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 52 member 2 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene epiplakin 1 Neighboring gene uncharacterized LOC137488510 Neighboring gene eukaryotic translation initiation factor 3, subunit E, b Neighboring gene uncharacterized LOC137488511

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Novel biallelic variants in the PLEC gene are associated with severe hearing loss. Zhang T, et al. Hear Res, 2023 Sep 1. PMID 37393735
    2. MiR-202-3p determines embryo viability during mid-blastula transition. Hu R, et al. Front Cell Dev Biol, 2022. PMID 36003151, Free PMC Article
    3. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Giera S, et al. Elife, 2018 May 29. PMID 29809138, Free PMC Article
    4. Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Li Z, et al. Environ Pollut, 2020 Jul. PMID 32146360
    5. In vivo characterization of human myofibrillar myopathy genes in zebrafish. Bührdel JB, et al. Biochem Biophys Res Commun, 2015 May 29. PMID 25866181

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intermediate filament cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    plectin a
    Names
    plec

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100032.1 → NP_001093502.1  plectin a isoform 1

      Status: VALIDATED

      Source sequence(s)
      CR855260
      UniProtKB/TrEMBL
      A0A8M1NF92, A0A8M9PGJ7, A5WV02
      Related
      ENSDARP00000085112.5, ENSDART00000090679.7
      Conserved Domains (13) summary
      smart00150
      Location:534 → 628
      SPEC; Spectrin repeats
      smart00250
      Location:2773 → 2810
      PLEC; Plectin repeat
      COG1196
      Location:965 → 1664
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:44 → 146
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:629 → 819
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:161 → 258
      CH; Calponin homology (CH) domain
      pfam00681
      Location:4042 → 4083
      Plectin; Plectin repeat
      pfam01576
      Location:1351 → 2450
      Myosin_tail_1; Myosin tail
      cd16269
      Location:2586 → 2597
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:1132 → 1302
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl12013
      Location:2206 → 2440
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:821 → 866
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:2525 → 2614
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001430891.1 → NP_001417820.1  plectin a isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX957242, CR855260
      UniProtKB/TrEMBL
      A0A8M9PNF5, A0A8M9PRP2, E7F8G7
      Related
      ENSDARP00000085102.5, ENSDART00000090669.7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      22408308..22621646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468103.2 → XP_021323778.1  plectin a isoform X5

      UniProtKB/TrEMBL
      A0A286YBE9, A0A8M9PB19, A0A8M9PNF5
      Related
      ENSDARP00000144502.1, ENSDART00000175106.2
      Conserved Domains (9) summary
      smart00150
      Location:719 → 813
      SPEC; Spectrin repeats
      smart00250
      Location:2969 → 3006
      PLEC; Plectin repeat
      COG5069
      Location:223 → 445
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:814 → 1004
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4238 → 4277
      Plectin; Plectin repeat
      cl17036
      Location:1006 → 1051
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1234 → 1780
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1974 → 2819
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3223 → 3261
      Plectin; Plectin repeat

    2. XM_068215164.1 → XP_068071265.1  plectin a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PNF5

    3. XM_021468104.2 → XP_021323779.1  plectin a isoform X6

      UniProtKB/TrEMBL
      A0A8M9PGI1, A0A8M9PNF5
      Conserved Domains (9) summary
      smart00150
      Location:724 → 818
      SPEC; Spectrin repeats
      smart00250
      Location:2963 → 3000
      PLEC; Plectin repeat
      COG5069
      Location:223 → 450
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:819 → 1009
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4232 → 4271
      Plectin; Plectin repeat
      cl17036
      Location:1011 → 1056
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1155 → 1854
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1968 → 2813
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3217 → 3255
      Plectin; Plectin repeat

    4. XM_021468102.2 → XP_021323777.1  plectin a isoform X4

      UniProtKB/TrEMBL
      A0A8M9P1W1, A0A8M9PNF5
      Conserved Domains (9) summary
      smart00150
      Location:724 → 818
      SPEC; Spectrin repeats
      smart00250
      Location:2974 → 3011
      PLEC; Plectin repeat
      COG5069
      Location:223 → 450
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:819 → 1009
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4243 → 4282
      Plectin; Plectin repeat
      cl17036
      Location:1011 → 1056
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1239 → 1785
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1979 → 2824
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3228 → 3266
      Plectin; Plectin repeat

    5. XM_021468101.2 → XP_021323776.1  plectin a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PNE8, A0A8M9PNF5
      Conserved Domains (9) summary
      smart00150
      Location:736 → 830
      SPEC; Spectrin repeats
      smart00250
      Location:2975 → 3012
      PLEC; Plectin repeat
      COG5069
      Location:223 → 462
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:831 → 1021
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4244 → 4283
      Plectin; Plectin repeat
      cl17036
      Location:1023 → 1068
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1167 → 1866
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1980 → 2825
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3229 → 3267
      Plectin; Plectin repeat

    6. XM_021468100.2 → XP_021323775.1  plectin a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PNF5, A0A8M9PRN8
      Conserved Domains (9) summary
      smart00150
      Location:736 → 830
      SPEC; Spectrin repeats
      smart00250
      Location:2986 → 3023
      PLEC; Plectin repeat
      COG5069
      Location:223 → 462
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:831 → 1021
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4255 → 4294
      Plectin; Plectin repeat
      cl17036
      Location:1023 → 1068
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1251 → 1797
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1991 → 2836
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3240 → 3278
      Plectin; Plectin repeat

    7. XM_021468117.2 → XP_021323792.1  plectin a isoform X17

      UniProtKB/TrEMBL
      A0A8M9P1X0, A0A8M9PGJ7
      Related
      ENSDARP00000150293.1, ENSDART00000182888.1
      Conserved Domains (9) summary
      smart00150
      Location:538 → 632
      SPEC; Spectrin repeats
      smart00250
      Location:2788 → 2825
      PLEC; Plectin repeat
      COG5069
      Location:35 → 264
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:633 → 823
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4057 → 4096
      Plectin; Plectin repeat
      cl17036
      Location:825 → 870
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1053 → 1599
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1793 → 2638
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3042 → 3080
      Plectin; Plectin repeat

    8. XM_021468115.2 → XP_021323790.1  plectin a isoform X15

      UniProtKB/TrEMBL
      A0A8M9PGJ7, A0A8M9PRQ7
      Conserved Domains (9) summary
      smart00150
      Location:543 → 637
      SPEC; Spectrin repeats
      smart00250
      Location:2793 → 2830
      PLEC; Plectin repeat
      COG5069
      Location:35 → 269
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:638 → 828
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4062 → 4101
      Plectin; Plectin repeat
      cl17036
      Location:830 → 875
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1058 → 1604
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1798 → 2643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3047 → 3085
      Plectin; Plectin repeat

    9. XM_021468120.2 → XP_021323795.1  plectin a isoform X19

      UniProtKB/TrEMBL
      A0A2R8PVX9, A0A8M9PGJ7, A0A8M9PRR5
      Related
      ENSDARP00000145064.1, ENSDART00000188208.1
      Conserved Domains (9) summary
      smart00150
      Location:526 → 620
      SPEC; Spectrin repeats
      smart00250
      Location:2776 → 2813
      PLEC; Plectin repeat
      COG5069
      Location:35 → 252
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:621 → 811
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4045 → 4084
      Plectin; Plectin repeat
      cl17036
      Location:813 → 858
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1041 → 1587
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1781 → 2626
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3030 → 3068
      Plectin; Plectin repeat

    10. XM_021468116.2 → XP_021323791.1  plectin a isoform X16

      UniProtKB/TrEMBL
      A0A8M9PGJ7, A0A8M9PNG8
      Conserved Domains (9) summary
      smart00150
      Location:538 → 632
      SPEC; Spectrin repeats
      smart00250
      Location:2788 → 2825
      PLEC; Plectin repeat
      COG5069
      Location:35 → 264
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:633 → 823
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4057 → 4096
      Plectin; Plectin repeat
      cl17036
      Location:825 → 870
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1053 → 1599
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1793 → 2638
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3042 → 3080
      Plectin; Plectin repeat

    11. XM_021468114.2 → XP_021323789.1  plectin a isoform X14

      UniProtKB/TrEMBL
      A0A8M9PGJ1, A0A8M9PGJ7
      Conserved Domains (9) summary
      smart00150
      Location:543 → 637
      SPEC; Spectrin repeats
      smart00250
      Location:2793 → 2830
      PLEC; Plectin repeat
      COG5069
      Location:35 → 269
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:638 → 828
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4062 → 4101
      Plectin; Plectin repeat
      cl17036
      Location:830 → 875
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1058 → 1604
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1798 → 2643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3047 → 3085
      Plectin; Plectin repeat

    12. XM_021468113.2 → XP_021323788.1  plectin a isoform X13

      UniProtKB/TrEMBL
      A0A8M9PB27, A0A8M9PGJ7
      Related
      ENSDARP00000156014.1, ENSDART00000185370.1
      Conserved Domains (9) summary
      smart00150
      Location:545 → 639
      SPEC; Spectrin repeats
      smart00250
      Location:2795 → 2832
      PLEC; Plectin repeat
      COG5069
      Location:37 → 271
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:640 → 830
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4064 → 4103
      Plectin; Plectin repeat
      cl17036
      Location:832 → 877
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1060 → 1606
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1800 → 2645
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3049 → 3087
      Plectin; Plectin repeat

    13. XM_021468110.2 → XP_021323785.1  plectin a isoform X10

      UniProtKB/TrEMBL
      A0A8M9PGJ7, A0A8M9PRQ0
      Conserved Domains (9) summary
      smart00150
      Location:550 → 644
      SPEC; Spectrin repeats
      smart00250
      Location:2800 → 2837
      PLEC; Plectin repeat
      COG5069
      Location:37 → 276
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:645 → 835
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4069 → 4108
      Plectin; Plectin repeat
      cl17036
      Location:837 → 882
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1065 → 1611
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1805 → 2650
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3054 → 3092
      Plectin; Plectin repeat

    14. XM_021468112.1 → XP_021323787.1  plectin a isoform X12

      UniProtKB/TrEMBL
      A0A2R8RIJ1, A0A8M9P1W8, A0A8M9PGJ7
      Related
      ENSDARP00000145708.1, ENSDART00000179856.1
      Conserved Domains (9) summary
      smart00150
      Location:545 → 639
      SPEC; Spectrin repeats
      smart00250
      Location:2795 → 2832
      PLEC; Plectin repeat
      COG5069
      Location:49 → 271
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:640 → 830
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4064 → 4103
      Plectin; Plectin repeat
      cl17036
      Location:832 → 877
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1060 → 1606
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1800 → 2645
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3049 → 3087
      Plectin; Plectin repeat

    15. XM_021468108.1 → XP_021323783.1  plectin a isoform X8

      UniProtKB/TrEMBL
      A0A8M9PB23, A0A8M9PGJ7
      Conserved Domains (9) summary
      smart00150
      Location:557 → 651
      SPEC; Spectrin repeats
      smart00250
      Location:2807 → 2844
      PLEC; Plectin repeat
      COG5069
      Location:49 → 283
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:652 → 842
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4076 → 4115
      Plectin; Plectin repeat
      cl17036
      Location:844 → 889
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1072 → 1618
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1812 → 2657
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3061 → 3099
      Plectin; Plectin repeat

    16. XM_021468107.1 → XP_021323782.1  plectin a isoform X7

      UniProtKB/TrEMBL
      A0A8M9P1W5, A0A8M9PGJ7
      Conserved Domains (9) summary
      smart00150
      Location:562 → 656
      SPEC; Spectrin repeats
      smart00250
      Location:2812 → 2849
      PLEC; Plectin repeat
      COG5069
      Location:49 → 288
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:657 → 847
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4081 → 4120
      Plectin; Plectin repeat
      cl17036
      Location:849 → 894
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1077 → 1623
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1817 → 2662
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3066 → 3104
      Plectin; Plectin repeat

    17. XM_021468118.2 → XP_021323793.1  plectin a isoform X18

      UniProtKB/TrEMBL
      A0A8M9PB30, A0A8M9PGJ7
      Related
      ENSDARP00000136093.2, ENSDART00000160153.2
      Conserved Domains (9) summary
      smart00150
      Location:534 → 628
      SPEC; Spectrin repeats
      smart00250
      Location:2784 → 2821
      PLEC; Plectin repeat
      COG5069
      Location:43 → 260
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:629 → 819
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4053 → 4092
      Plectin; Plectin repeat
      cl17036
      Location:821 → 866
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1049 → 1595
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1789 → 2634
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3038 → 3076
      Plectin; Plectin repeat

    18. XM_021468111.2 → XP_021323786.1  plectin a isoform X11

      UniProtKB/TrEMBL
      A0A8M9PGJ7, A0A8M9PNG2
      Conserved Domains (9) summary
      smart00150
      Location:546 → 640
      SPEC; Spectrin repeats
      smart00250
      Location:2796 → 2833
      PLEC; Plectin repeat
      COG5069
      Location:43 → 272
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:641 → 831
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4065 → 4104
      Plectin; Plectin repeat
      cl17036
      Location:833 → 878
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1061 → 1607
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1801 → 2646
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3050 → 3088
      Plectin; Plectin repeat

    19. XM_021468109.2 → XP_021323784.1  plectin a isoform X9

      UniProtKB/TrEMBL
      A0A8M9PGI7, A0A8M9PGJ7
      Conserved Domains (9) summary
      smart00150
      Location:551 → 645
      SPEC; Spectrin repeats
      smart00250
      Location:2801 → 2838
      PLEC; Plectin repeat
      COG5069
      Location:43 → 277
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:646 → 836
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4070 → 4109
      Plectin; Plectin repeat
      cl17036
      Location:838 → 883
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:1066 → 1612
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:1806 → 2651
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27652
      Location:3055 → 3093
      Plectin; Plectin repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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