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    cryl1 crystallin, lambda 1 [ Danio rerio (zebrafish) ]

    Gene ID: 751596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cryl1provided by ZNC
    Official Full Name
    crystallin, lambda 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-7
    See related
    Ensembl:ENSDARG00000003675 AllianceGenome:ZFIN:ZDB-GENE-060810-7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6895749; zgc:152659
    Summary
    Predicted to enable L-gulonate 3-dehydrogenase activity. Predicted to act upstream of or within fatty acid metabolic process. Orthologous to human CRYL1 (crystallin lambda 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cryl1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21383672..21399636)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21572803..21588767)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene interleukin 17d Neighboring gene intraflagellar transport 88 homolog Neighboring gene gap junction protein beta 8 Neighboring gene gap junction protein, alpha 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Retinoblastoma binding protein 6 and crystallin lambda 1 are cadmium-responsive genes in zebrafish embryos and adults retinae. Scudiero R, et al. C R Biol, 2017 Apr. PMID 28385620
    2. Lens defects in Astyanax mexicanus Cavefish: evolution of crystallins and a role for alphaA-crystallin. Hinaux H, et al. Dev Neurobiol, 2015 May. PMID 25348293
    3. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152659

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-gulonate 3-dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-gulonate 3-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    lambda-crystallin homolog
    NP_001038806.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045341.1 → NP_001038806.1  lambda-crystallin homolog

      See identical proteins and their annotated locations for NP_001038806.1

      Status: PROVISIONAL

      Source sequence(s)
      BC121722
      UniProtKB/TrEMBL
      Q0V973
      Related
      ENSDARP00000145972.1, ENSDART00000180081.1
      Conserved Domains (3) summary
      PRK06129
      Location:9 → 314
      PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated
      pfam00725
      Location:192 → 262
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:9 → 187
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      21383672..21399636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394749.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      249364..265328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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