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    ect2 epithelial cell transforming 2 [ Danio rerio (zebrafish) ]

    Gene ID: 445406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ect2provided by ZNC
    Official Full Name
    epithelial cell transforming 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040831-2
    See related
    Ensembl:ENSDARG00000007278 AllianceGenome:ZFIN:ZDB-GENE-040831-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within cytokinetic process. Predicted to be located in cytoplasm. Predicted to be active in cell cortex and nucleus. Is expressed in midbrain. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ect2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (10388636..10456387, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (10404944..10472703, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885993 Neighboring gene neuroligin 1 Neighboring gene uncharacterized LOC137496674 Neighboring gene uncharacterized LOC108191587 Neighboring gene MCF.2 cell line derived transforming sequence-like 2 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. González-Rosa JM, et al. Dev Cell, 2018 Feb 26. PMID 29486195, Free PMC Article
    2. Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Chen J, et al. Sci China Life Sci, 2021 Dec. PMID 33751369
    3. Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development. Silic MR, et al. Dev Dyn, 2021 Oct. PMID 33728688, Free PMC Article
    4. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
    5. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cytokinesis, actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein ECT2
    Names
    epithelial cell transforming sequence 2 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003883.1 → NP_001003883.1  protein ECT2

      See identical proteins and their annotated locations for NP_001003883.1

      Status: PROVISIONAL

      Source sequence(s)
      AY648840
      UniProtKB/TrEMBL
      A0A8M1N1X0, Q6DRB9
      Related
      ENSDARP00000004102.5, ENSDART00000011087.6
      Conserved Domains (4) summary
      cd01229
      Location:597 → 770
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:237 → 312
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:422 → 606
      RhoGEF; RhoGEF domain
      pfam12738
      Location:149 → 213
      PTCB-BRCT; twin BRCT domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      10388636..10456387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224147.1 → XP_068080248.1  protein ECT2 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B1X0, F1QVS6

    2. XM_005155717.5 → XP_005155774.1  protein ECT2 isoform X1

      See identical proteins and their annotated locations for XP_005155774.1

      UniProtKB/TrEMBL
      A0A0R4IKD5, A0A8M2B2N3
      Conserved Domains (4) summary
      cd01229
      Location:665 → 838
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:269 → 344
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:490 → 673
      RhoGEF; RhoGEF domain
      pfam12738
      Location:181 → 245
      PTCB-BRCT; twin BRCT domain

    3. XM_068224148.1 → XP_068080249.1  protein ECT2 isoform X5

      Related
      ENSDARP00000146880.1, ENSDART00000188276.1

    4. XM_068224149.1 → XP_068080250.1  protein ECT2 isoform X6

    5. XM_068224146.1 → XP_068080247.1  protein ECT2 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B1X0, F1QVS6

    6. XM_021479597.2 → XP_021335272.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IKD5, A0A8M2B2N3
      Conserved Domains (4) summary
      cd01229
      Location:665 → 838
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:269 → 344
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:490 → 673
      RhoGEF; RhoGEF domain
      pfam12738
      Location:181 → 245
      PTCB-BRCT; twin BRCT domain

    7. XM_005155719.5 → XP_005155776.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A2R8Q1Z1, A0A8M2B2H0
      Related
      ENSDARP00000144703.1, ENSDART00000185574.1
      Conserved Domains (4) summary
      cd01229
      Location:633 → 806
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:237 → 312
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:458 → 642
      RhoGEF; RhoGEF domain
      pfam12738
      Location:149 → 213
      PTCB-BRCT; twin BRCT domain

    8. XM_005155720.4 → XP_005155777.1  protein ECT2 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B1X0, F1QVS6
      Related
      ENSDARP00000076266.2, ENSDART00000081827.4
      Conserved Domains (4) summary
      cd01229
      Location:629 → 802
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:269 → 344
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:454 → 638
      RhoGEF; RhoGEF domain
      pfam12738
      Location:181 → 245
      PTCB-BRCT; twin BRCT domain

    9. XM_005155721.4 → XP_005155778.1  protein ECT2 isoform X4

      UniProtKB/TrEMBL
      A0A8M2B1T9
      Conserved Domains (4) summary
      cd01229
      Location:665 → 838
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:269 → 344
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:490 → 674
      RhoGEF; RhoGEF domain
      pfam12738
      Location:181 → 245
      PTCB-BRCT; twin BRCT domain

    10. XM_021479596.2 → XP_021335271.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IKD5, A0A8M2B2N3
      Related
      ENSDARP00000134213.1, ENSDART00000169509.3
      Conserved Domains (4) summary
      cd01229
      Location:665 → 838
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:269 → 344
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:490 → 673
      RhoGEF; RhoGEF domain
      pfam12738
      Location:181 → 245
      PTCB-BRCT; twin BRCT domain
    Nucleotide Protein Strain
    Heading Accession and Version

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