klf1 Kruppel like factor 1 (erythroid) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klf1provided by ZNC
Official Full Name: Kruppel like factor 1 (erythroid)provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-55
See related: Ensembl:ENSDARG00000017400 AllianceGenome:ZFIN:ZDB-GENE-980526-55
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: klfd; zgc:194069
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ regeneration; cardiac muscle tissue development; and sarcomere organization. Acts upstream of or within positive regulation of gene expression; primitive erythrocyte differentiation; and regulation of primitive erythrocyte differentiation. Located in chromatin. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; and posterior lateral plate mesoderm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (KLF transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (8129543..8140958)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (7894004..7905419)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.
Title: Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.
Kruppel-like factor 1 is a core cardiomyogenic trigger in zebrafish.
Title: Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fc02h08.x1 (e-PCR)
- UniSTS:192089

fc38a08.x1 (e-PCR)
- UniSTS:193720

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell dedifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primitive erythrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of primitive erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Kruppel-like factor 1

Names: Krueppel-like factor 1; Kruppel-like factor d; erythroid krueppel-like transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130936.1 → NP_571011.1 Kruppel-like factor 1

See identical proteins and their annotated locations for NP_571011.1

Status: PROVISIONAL

Source sequence(s)

AF392996

UniProtKB/Swiss-Prot

Q90XE6

Related

ENSDARP00000020778.5, ENSDART00000011724.7

Conserved Domains (4) summary

COG5048
Location:287 → 344

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:287 → 306

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:328 → 353

zf-H2C2_2; Zinc-finger double domain

cd21581
Location:6 → 282

KLF1_N; N-terminal domain of Kruppel-like Factor 1