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    gpt2 glutamic pyruvate transaminase (alanine aminotransferase) 2 [ Danio rerio (zebrafish) ]

    Gene ID: 799963, updated on 4-Jan-2025

    Summary

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    Official Symbol
    gpt2provided by ZNC
    Official Full Name
    glutamic pyruvate transaminase (alanine aminotransferase) 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030729-8
    See related
    Ensembl:ENSDARG00000012199 AllianceGenome:ZFIN:ZDB-GENE-030729-8
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb580; im:7150662; zgc:165657
    Summary
    Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-alanine catabolic process. Predicted to act upstream of or within biosynthetic process. Is expressed in several structures, including axial chorda mesoderm; axis; immature eye; musculature system; and nervous system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See gpt2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41887378..41900076)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41607710..41619117)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene origin recognition complex, subunit 6 Neighboring gene myosin light chain kinase 3 Neighboring gene zgc:92818 Neighboring gene DnaJ heat shock protein family (Hsp40) member A2a Neighboring gene afadin- and alpha-actinin-binding protein-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation. Zielonka M, et al. Exp Neurol, 2019 Apr. PMID 30653968
    2. Knock-Down of Histidyl-tRNA Synthetase Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells in vivo. Waldron A, et al. Front Cell Dev Biol, 2019. PMID 31134197, Free PMC Article
    3. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Mirando AC, et al. Sci Rep, 2015 Aug 14. PMID 26271225, Free PMC Article
    4. Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Zhu QS, et al. Nutr Metab (Lond), 2020. PMID 32818036, Free PMC Article
    5. Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase. Zielonka M, et al. PLoS One, 2018. PMID 30199544, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC165657

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-alanine:2-oxoglutarate aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    alanine aminotransferase 2
    NP_001092227.2
    XP_068078523.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098757.2 → NP_001092227.2  alanine aminotransferase 2

      Status: VALIDATED

      Source sequence(s)
      CU672230
      UniProtKB/TrEMBL
      A0A8M1NDP9
      Related
      ENSDARP00000104098.3, ENSDART00000115090.7
      Conserved Domains (2) summary
      cd00609
      Location:83 → 471
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:2 → 481
      PTZ00377; alanine aminotransferase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      41887378..41900076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222422.1 → XP_068078523.1  alanine aminotransferase 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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