slc16a12b solute carrier family 16 member 12b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc16a12bprovided by ZNC
Official Full Name: solute carrier family 16 member 12bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-80
See related: Ensembl:ENSDARG00000089885 AllianceGenome:ZFIN:ZDB-GENE-050522-80
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7140871; wu:fc44b08; zgc:110441
Summary: Predicted to enable creatine transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity; and uniporter activity. Predicted to be involved in creatine transmembrane transport and creatinine metabolic process. Predicted to act upstream of or within transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (16967716..16986968)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (16845842..16865094)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc37b12.x1 (e-PCR)
- UniSTS:188058

fc44b08 (e-PCR)
- UniSTS:189158

fj17b03.y1 (e-PCR)
- UniSTS:198653

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables creatine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uniporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in creatine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in creatine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in creatinine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: monocarboxylate transporter 12-B

Names: MCT 12-B; solute carrier family 16 (monocarboxylic acid transporters), member 12b; solute carrier family 16 member 12-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145814.1 → NP_001139286.1 monocarboxylate transporter 12-B

Status: PROVISIONAL

Source sequence(s)

BX000534

UniProtKB/Swiss-Prot

Q503M4

UniProtKB/TrEMBL

A0A8M1NTF7, F1Q846

Related

ENSDARP00000115335.1, ENSDART00000138174.2

Conserved Domains (2) summary

cd06174
Location:33 → 430

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:37 → 407

MFS_1; Major Facilitator Superfamily