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    hlcs holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) [ Danio rerio (zebrafish) ]

    Gene ID: 337784, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hlcsprovided by ZNC
    Official Full Name
    holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5333
    See related
    Ensembl:ENSDARG00000039934 AllianceGenome:ZFIN:ZDB-GENE-030131-5333
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    est269366; im:6962365; ig:est269366
    Summary
    Predicted to enable biotin--[biotin carboxyl-carrier protein] ligase activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hlcs in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (53703..59173, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (53691..59188, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene SIM bHLH transcription factor 2 Neighboring gene dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a Neighboring gene VPS26 endosomal protein sorting factor C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays. Lindeman LC, et al. PLoS One, 2010 Dec 20. PMID 21187971, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    biotin--protein ligase
    Names
    holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
    XP_068080154.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      53703..59173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224053.1 → XP_068080154.1  biotin--protein ligase

      UniProtKB/TrEMBL
      A0A8M1RR82
      Related
      ENSDARP00000058410.6, ENSDART00000058411.6
    Nucleotide Protein Strain
    Heading Accession and Version

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