cxadr CXADR Ig-like cell adhesion molecule [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cxadrprovided by ZNC
Official Full Name: CXADR Ig-like cell adhesion moleculeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020814-2
See related: Ensembl:ENSDARG00000043658 AllianceGenome:ZFIN:ZDB-GENE-020814-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: car; cb331; fb76g12; wu:fb76g12
Summary: Enables virus receptor activity. Acts upstream of or within kidney development. Located in bicellular tight junction and cell surface. Is expressed in several structures, including digestive system; epithelium; heart; nervous system; and pronephros. Orthologous to human CXADR (CXADR Ig-like cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (27096055..27158240)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (27134407..27196527)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results establish a requirement for CAR in the terminal differentiation of renal glomerular and tubular cell types.
Title: The coxsackie and adenovirus receptor (CAR) is required for renal epithelial differentiation within the zebrafish pronephros.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in homotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coxsackievirus and adenovirus receptor homolog

Names: adenovirus receptor; coxsackie virus and adenovirus receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152948.2 → NP_694480.1 coxsackievirus and adenovirus receptor homolog precursor

See identical proteins and their annotated locations for NP_694480.1

Status: VALIDATED

Source sequence(s)

BX248510

UniProtKB/Swiss-Prot

Q804R4, Q90Y50

UniProtKB/TrEMBL

B7ZUW2

Related

ENSDARP00000064106.6, ENSDART00000064107.8

Conserved Domains (4) summary

smart00410
Location:32 → 141

IG_like; Immunoglobulin like

pfam07679
Location:141 → 233

I-set; Immunoglobulin I-set domain

pfam07686
Location:28 → 141

V-set; Immunoglobulin V-set domain

pfam13927
Location:147 → 220

Ig_3; Immunoglobulin domain