prdx1 peroxiredoxin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prdx1provided by ZNC
Official Full Name: peroxiredoxin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-35
See related: Ensembl:ENSDARG00000058734 AllianceGenome:ZFIN:ZDB-GENE-050320-35
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NKEF-A; zgc:110343; hm:zehl0637
Summary: Predicted to enable thioredoxin peroxidase activity. Acts upstream of or within leukocyte activation. Part of protein-containing complex. Is expressed in several structures, including diencephalon; digestive system; epidermis; lateral line; and otic vesicle. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (6106491..6127045, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (6194609..6203807, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this paper shows immunotimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model
Title: Stimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model.
HDAC6 inhibition and the regulation of Prx1 activity may play a significant role in protecting retinal cells and in particular photoreceptors.
Title: HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness.
Data suggest a role for peroxiredoxin1 (Prdx1) in vasculature and indicating that the antioxidant function of prdx1 is important.
Title: Prdx1-encoded peroxiredoxin is important for vascular development in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-1

NP_001013489.2

EC 1.11.1.7

XP_068080070.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013471.2 → NP_001013489.2 peroxiredoxin-1

Status: VALIDATED

Source sequence(s)

BI841658, CU467854, EH539742

UniProtKB/TrEMBL

A0A0R4IYJ8, A0A8M1N4M2, A2AWE1, F1RA95

Related

ENSDARP00000076104.3, ENSDART00000081663.6

Conserved Domains (2) summary

PTZ00253
Location:1 → 199

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:8 → 180

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...