cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp19a1bprovided by ZNC
Official Full Name: cytochrome P450, family 19, subfamily A, polypeptide 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-001103-4
See related: Ensembl:ENSDARG00000098360 AllianceGenome:ZFIN:ZDB-GENE-001103-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: AroB; cyp19; cyp19b; CYP19a2; P450aromB; zgc:92614
Summary: Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Acts upstream of or within several processes, including response to estradiol; response to estrogen; and response to steroid hormone. Predicted to be located in membrane. Is expressed in several structures, including brain; cranial nerve; gonad; head; and radial glial cell. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (4890767..4904435, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (4764339..4777990, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Embryonic exposures to chemicals acting on brain aromatase lead to different locomotor effects in zebrafish larvae.
Title: Embryonic exposures to chemicals acting on brain aromatase lead to different locomotor effects in zebrafish larvae.
Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish.
Title: Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish.
The whole-body androgen levels, follicle-stimulating hormone beta and luteinizing hormone beta protein levels in the pituitary, and transcript levels of genes known to be involved in spermatogenesis and steroidogenesis in the testes were significantly higher in the cyp19a1a mutant and aromatase double-mutant males than in the wild-type and cyp19a1b mutant male.
Title: New Insights Into the Role of Estrogens in Male Fertility Based on Findings in Aromatase-Deficient Zebrafish.
complete and detailed mapping of Blbp-Blbp expression in the brain, its co-expression with AroB, and its link with radial glial cells proliferation in zebrafish
Title: Mapping of brain lipid binding protein (Blbp) in the brain of adult zebrafish, co-expression with aromatase B and links with proliferation.
Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
Title: Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio).
Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).
Title: Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio).
These results indicate that basal expression of cyp19a1b expression in the brain of developing zebrafish most likely relies upon expression of esr that are fully functional before 25 hpf.
Title: Early regulation of brain aromatase (cyp19a1b) by estrogen receptors during zebrafish development.
genistein regulates aromatase-B expression in the brain in an ER-dependent manner
Title: The phytoestrogen genistein affects zebrafish development through two different pathways.
To understand the function of AroB in the brain, transgenic GFP was driven by the brain aromatase cyp19a1b promoter. GFP was found in the radial glial cells that overlap with AroB immunoreactivity in the correct temporal and spatial pattern.
Title: A cyp19a1b-gfp (aromatase B) transgenic zebrafish line that expresses GFP in radial glial cells.
Cyp19b is regulated by estrogens.Promoter sequence involved in the strong estrogen inducibility of cyp19b which is specific for glial cells is identified.
Title: Characterization of a cis-acting element involved in cell-specific expression of the zebrafish brain aromatase gene.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to estrogen	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 19A1B

Names: aromatase B; brain aromatase; cytochrome P450 aromatase; cytochrome P450, 19b

NP_571717.2

EC 1.14.14.14

XP_021326198.1

EC 1.14.14.14

XP_068073513.1

EC 1.14.14.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131642.2 → NP_571717.2 cytochrome P450 19A1B

Status: VALIDATED

Source sequence(s)

AL954697

UniProtKB/TrEMBL

E7F491, Q5U870

Related

ENSDART00000161085.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

4890767..4904435 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470523.2 → XP_021326198.1 cytochrome P450 19A1B isoform X1

UniProtKB/TrEMBL

A0A8M9PGW6

Conserved Domains (1) summary

pfam00067
Location:48 → 482

p450; Cytochrome P450
XM_068217412.1 → XP_068073513.1 cytochrome P450 19A1B isoform X2