ca2 carbonic anhydrase II [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ca2provided by ZNC
Official Full Name: carbonic anhydrase IIprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031219-5
See related: Ensembl:ENSDARG00000014488 AllianceGenome:ZFIN:ZDB-GENE-031219-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ca2a; CA17a; cb1082; wu:fb50f02; wu:fk91a02
Summary: Enables carbonate dehydratase activity. Acts upstream of or within several processes, including carbon dioxide transport; hypotonic salinity response; and sodium ion import across plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gill; integument; nervous system; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to several human genes including CA2 (carbonic anhydrase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (32646779..32664669, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (32732136..32749999, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

AI477215 (e-PCR)
- UniSTS:206509

fk91a02.x1 (e-PCR)
- UniSTS:201704

fb50f02.x1 (e-PCR)
- UniSTS:203254

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables carbonate dehydratase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables carbonate dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbon dioxide transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within carbon dioxide transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within carbon dioxide transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hypotonic salinity response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of pH	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: carbonic anhydrase 2

Names: zCA2-like a

NP_954685.2

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199215.2 → NP_954685.2 carbonic anhydrase 2

Status: VALIDATED

Source sequence(s)

CR792422

UniProtKB/TrEMBL

Q6PFU7

Related

ENSDARP00000034327.6, ENSDART00000038364.9

Conserved Domains (1) summary

cl00012
Location:1 → 259

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...