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    Pigw phosphatidylinositol glycan anchor biosynthesis, class W [ Mus musculus (house mouse) ]

    Gene ID: 70325, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pigwprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Wprovided by MGI
    Primary source
    MGI:MGI:1917575
    See related
    Ensembl:ENSMUSG00000045140 AllianceGenome:MGI:1917575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gwt1; PIG-W; 2610044A17Rik
    Summary
    Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 2.4), liver E14.5 (RPKM 2.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pigw in Genome Data Viewer
    Location:
    11 C; 11 51.34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84767139..84771111, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84876313..84880285, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930502E09 gene Neighboring gene STARR-positive B cell enhancer ABC_E3986 Neighboring gene gametogenetin binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_30226 Neighboring gene STARR-seq mESC enhancer starr_30227 Neighboring gene STARR-positive B cell enhancer ABC_E7033 Neighboring gene gametogenetin binding protein 2, opposite strand Neighboring gene myosin XIX Neighboring gene zinc finger, HIT type 3 Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process  
    involved_in GPI anchor biosynthetic process  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    phosphatidylinositol-glycan biosynthesis class W protein
    Names
    phosphatidylinositol glycan, class W

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077636.1NP_001071104.1  phosphatidylinositol-glycan biosynthesis class W protein

      See identical proteins and their annotated locations for NP_001071104.1

      Status: VALIDATED

      Source sequence(s)
      AK086537, CD547872
      Consensus CDS
      CCDS36263.1
      UniProtKB/Swiss-Prot
      Q8C398, Q8C4S0, Q9CSX1
      UniProtKB/TrEMBL
      B7ZN11
      Related
      ENSMUSP00000103715.3, ENSMUST00000108080.3
      Conserved Domains (1) summary
      cl02109
      Location:4502
      GWT1; GWT1
    2. NM_001363112.1NP_001350041.1  phosphatidylinositol-glycan biosynthesis class W protein

      Status: VALIDATED

      Source sequence(s)
      AL645623, BC144942
      Consensus CDS
      CCDS36263.1
      UniProtKB/Swiss-Prot
      Q8C398, Q8C4S0, Q9CSX1
      UniProtKB/TrEMBL
      B7ZN11
      Conserved Domains (1) summary
      cl02109
      Location:4502
      GWT1; GWT1
    3. NM_027388.2NP_081664.2  phosphatidylinositol-glycan biosynthesis class W protein

      See identical proteins and their annotated locations for NP_081664.2

      Status: VALIDATED

      Source sequence(s)
      AK086537, BB647852, CD547872
      Consensus CDS
      CCDS36263.1
      UniProtKB/Swiss-Prot
      Q8C398, Q8C4S0, Q9CSX1
      UniProtKB/TrEMBL
      B7ZN11
      Related
      ENSMUSP00000064547.3, ENSMUST00000067058.3
      Conserved Domains (1) summary
      cl02109
      Location:4502
      GWT1; GWT1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      84767139..84771111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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