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    Snx19 sorting nexin 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx19provided by RGD
    Official Full Name
    sorting nexin 19provided by RGD
    Primary source
    RGD:1309857
    See related
    EnsemblRapid:ENSRNOG00000014719 AllianceGenome:RGD:1309857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to act upstream of or within several processes, including chondrocyte differentiation; dense core granule maturation; and insulin secretion. Predicted to be located in cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human SNX19 (sorting nexin 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 168.4), Kidney (RPKM 159.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx19 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (37088142..37125317)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (28829881..28867600)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (31497034..31534077)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 12 Neighboring gene ribosomal protein L30, pseudogene 5 Neighboring gene uncharacterized LOC134480009 Neighboring gene uncharacterized LOC134480010

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor. Kan A, et al. Arthritis Rheum, 2009 Nov. PMID 19877062
    2. Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling. Mas C, et al. J Biol Chem, 2014 Oct 10. PMID 25148684, Free PMC Article
    3. Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cells. Harashima S, et al. J Diabetes Investig, 2012 Feb 20. PMID 24843546, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dense core granule maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dense core granule maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108131.2 → NP_001101601.2  sorting nexin-19 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6ABN1
      Related
      ENSRNOP00000020041.7, ENSRNOT00000020041.8

    2. NM_001429801.1 → NP_001416730.1  sorting nexin-19 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6ABN1

    3. NM_001429802.1 → NP_001416731.1  sorting nexin-19 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6ABN1

    RNA

    1. NR_190791.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      37088142..37125317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242747.5 → XP_006242809.1  sorting nexin-19 isoform X1

      Conserved Domains (3) summary
      cd06893
      Location:440 → 567
      PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
      pfam08628
      Location:753 → 853
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:95 → 265
      PXA; PXA domain

    2. XM_063265353.1 → XP_063121423.1  sorting nexin-19 isoform X2

    RNA

    1. XR_005487808.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
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