Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndufaf7provided by RGD
Official Full Name: NADH:ubiquinone oxidoreductase complex assembly factor 7provided by RGD
Primary source: RGD:1311578
See related: EnsemblRapid:ENSRNOG00000005279 AllianceGenome:RGD:1311578
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311578
Summary: Predicted to enable enzyme binding activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine methylation, to symmetrical-dimethyl arginine. Predicted to be active in mitochondrion. Orthologous to human NDUFAF7 (NADH:ubiquinone oxidoreductase complex assembly factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 114.8), Heart (RPKM 94.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (21860788..21871965, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (16108630..16119810, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (1534594..1545831)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H2AQ104 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K37 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R17 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R2 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R26 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R8 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4R3 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N symmetric methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine omega-N symmetric methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N symmetric methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-arginine methylation, to symmetrical-dimethyl arginine	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-arginine methylation, to symmetrical-dimethyl arginine	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein arginine methyltransferase NDUFAF7, mitochondrial

Names: NADH dehydrogenase (ubiquinone) complex I, assembly factor 7; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7; protein midA homolog, mitochondrial

NP_001008319.1

EC 2.1.1.320

XP_038967822.1

EC 2.1.1.320

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008318.1 → NP_001008319.1 protein arginine methyltransferase NDUFAF7, mitochondrial precursor

See identical proteins and their annotated locations for NP_001008319.1

Status: PROVISIONAL

Source sequence(s)

BC083810

UniProtKB/Swiss-Prot

Q5XI79

UniProtKB/TrEMBL

A0A8L2UHW1, A6H9U5

Related

ENSRNOP00000084400.2, ENSRNOT00000109935.2

Conserved Domains (2) summary

COG1565
Location:46 → 402

MidA; SAM-dependent methyltransferase, MidA family [General function prediction only]

pfam02636
Location:95 → 349

Methyltransf_28; Putative S-adenosyl-L-methionine-dependent methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

21860788..21871965 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111894.2 → XP_038967822.1 protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6A175

Related

ENSRNOP00000098713.1, ENSRNOT00000149624.1

Conserved Domains (1) summary

pfam02636
Location:131 → 385

Methyltransf_28; Putative S-adenosyl-L-methionine-dependent methyltransferase