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    Epb41 erythrocyte membrane protein band 4.1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Epb41provided by RGD
    Official Full Name
    erythrocyte membrane protein band 4.1provided by RGD
    Primary source
    RGD:1564762
    See related
    EnsemblRapid:ENSRNOG00000010037 AllianceGenome:RGD:1564762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Epb4.1; RGD1564762
    Summary
    Enables actin binding activity and spectrin binding activity. Involved in protein-containing complex assembly. Located in cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in hereditary elliptocytosis. Orthologous to human EPB41 (erythrocyte membrane protein band 4.1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 422.3), Kidney (RPKM 205.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epb41 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149394080..149548178, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144110010..144264037, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150081727..150243186, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene transmembrane protein 200B Neighboring gene opioid receptor, delta 1 Neighboring gene YTH N6-methyladenosine RNA binding protein F2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein 4.1 in forebrain postsynaptic density preparations: enrichment of 4.1 gene products and detection of 4.1R binding proteins. Scott C, et al. Eur J Biochem, 2001 Feb. PMID 11179975
    2. Immunolocalization of protein 4.1B in the rat digestive system. Terada N, et al. J Mol Histol, 2004 May. PMID 15503808
    3. Homozygous 4.1(-) hereditary elliptocytosis associated with a point mutation in the downstream initiation codon of protein 4.1 gene. Dalla Venezia N, et al. J Clin Invest, 1992 Nov. PMID 1430200, Free PMC Article
    4. Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability. Tchernia G, et al. J Clin Invest, 1981 Aug. PMID 6894932, Free PMC Article
    5. Paranodin, a glycoprotein of neuronal paranodal membranes. Menegoz M, et al. Neuron, 1997 Aug. PMID 9292722

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intestinal absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein 4.1
    Names
    erythrocyte protein band 4.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399558.1 → NP_001386487.1  protein 4.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4A9A6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149394080..149548178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287563.1 → XP_063143633.1  protein 4.1 isoform X40

      UniProtKB/TrEMBL
      A0A0G2KAK2

    2. XM_063287556.1 → XP_063143626.1  protein 4.1 isoform X33

      UniProtKB/TrEMBL
      A0A0G2KAK2

    3. XM_063287555.1 → XP_063143625.1  protein 4.1 isoform X32

    4. XM_063287546.1 → XP_063143616.1  protein 4.1 isoform X22

    5. XM_063287551.1 → XP_063143621.1  protein 4.1 isoform X28

    6. XM_063287548.1 → XP_063143618.1  protein 4.1 isoform X25

    7. XM_063287554.1 → XP_063143624.1  protein 4.1 isoform X31

    8. XM_063287549.1 → XP_063143619.1  protein 4.1 isoform X26

    9. XM_063287550.1 → XP_063143620.1  protein 4.1 isoform X27

    10. XM_063287552.1 → XP_063143622.1  protein 4.1 isoform X29

    11. XM_063287567.1 → XP_063143637.1  protein 4.1 isoform X44

      UniProtKB/TrEMBL
      A0A0G2KAK2

    12. XM_063287562.1 → XP_063143632.1  protein 4.1 isoform X39

      UniProtKB/TrEMBL
      A0A0G2KAK2

    13. XM_063287558.1 → XP_063143628.1  protein 4.1 isoform X35

      UniProtKB/TrEMBL
      A0A0G2KAK2

    14. XM_063287568.1 → XP_063143638.1  protein 4.1 isoform X45

      UniProtKB/TrEMBL
      A0A0G2KAK2

    15. XM_063287565.1 → XP_063143635.1  protein 4.1 isoform X42

      UniProtKB/TrEMBL
      A0A0G2KAK2

    16. XM_063287573.1 → XP_063143643.1  protein 4.1 isoform X50

      UniProtKB/TrEMBL
      A0A0G2KAK2

    17. XM_063287566.1 → XP_063143636.1  protein 4.1 isoform X43

      UniProtKB/TrEMBL
      A0A0G2KAK2

    18. XM_063287560.1 → XP_063143630.1  protein 4.1 isoform X37

      UniProtKB/TrEMBL
      A0A0G2KAK2

    19. XM_063287570.1 → XP_063143640.1  protein 4.1 isoform X47

      UniProtKB/TrEMBL
      A0A0G2KAK2

    20. XM_063287572.1 → XP_063143642.1  protein 4.1 isoform X49

      UniProtKB/TrEMBL
      A0A0G2KAK2

    21. XM_063287557.1 → XP_063143627.1  protein 4.1 isoform X34

      UniProtKB/TrEMBL
      A0A0G2KAK2

    22. XM_063287571.1 → XP_063143641.1  protein 4.1 isoform X48

      UniProtKB/TrEMBL
      A0A0G2KAK2

    23. XM_063287561.1 → XP_063143631.1  protein 4.1 isoform X38

      UniProtKB/TrEMBL
      A0A0G2KAK2

    24. XM_063287564.1 → XP_063143634.1  protein 4.1 isoform X41

      UniProtKB/TrEMBL
      A0A0G2KAK2

    25. XM_063287559.1 → XP_063143629.1  protein 4.1 isoform X36

      UniProtKB/TrEMBL
      A0A0G2KAK2

    26. XM_063287569.1 → XP_063143639.1  protein 4.1 isoform X46

      UniProtKB/TrEMBL
      A0A0G2KAK2

    27. XM_039111260.1 → XP_038967188.1  protein 4.1 isoform X17

      UniProtKB/TrEMBL
      D4A9A6
      Conserved Domains (5) summary
      smart00295
      Location:210 → 400
      B41; Band 4.1 homologues
      cd13184
      Location:395 → 488
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:605 → 651
      SAB; SAB domain
      pfam05902
      Location:690 → 796
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:498 → 541
      FA; FERM adjacent (FA)

    28. XM_063287545.1 → XP_063143615.1  protein 4.1 isoform X19

      UniProtKB/TrEMBL
      A0A8I6A4E3

    29. XM_063287542.1 → XP_063143612.1  protein 4.1 isoform X10

      UniProtKB/TrEMBL
      D4A9A6

    30. XM_063287547.1 → XP_063143617.1  protein 4.1 isoform X24

      UniProtKB/TrEMBL
      A0A8I6A4E3

    31. XM_017593842.1 → XP_017449331.1  protein 4.1 isoform X16

      UniProtKB/TrEMBL
      D3ZKF7, D4A9A6
      Related
      ENSRNOP00000061387.2, ENSRNOT00000067349.6

    32. XM_063287544.1 → XP_063143614.1  protein 4.1 isoform X14

      UniProtKB/TrEMBL
      D4A9A6

    33. XM_063287543.1 → XP_063143613.1  protein 4.1 isoform X13

      UniProtKB/TrEMBL
      D4A9A6

    34. XM_017593843.1 → XP_017449332.1  protein 4.1 isoform X18

      UniProtKB/TrEMBL
      A0A8I6A4E3

    35. XM_063287540.1 → XP_063143610.1  protein 4.1 isoform X5

      UniProtKB/TrEMBL
      A6ISR5

    36. XM_063287539.1 → XP_063143609.1  protein 4.1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y1T6, A6ISR5
      Related
      ENSRNOP00000077988.1, ENSRNOT00000107222.2

    37. XM_017593838.1 → XP_017449327.1  protein 4.1 isoform X11

      UniProtKB/TrEMBL
      D4A9A6

    38. XM_063287538.1 → XP_063143608.1  protein 4.1 isoform X3

      UniProtKB/TrEMBL
      A6ISR5

    39. XM_039111259.1 → XP_038967187.1  protein 4.1 isoform X15

      UniProtKB/TrEMBL
      D4A9A6
      Conserved Domains (5) summary
      smart00295
      Location:210 → 400
      B41; Band 4.1 homologues
      cd13184
      Location:395 → 488
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:658 → 706
      SAB; SAB domain
      pfam05902
      Location:720 → 808
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:498 → 541
      FA; FERM adjacent (FA)

    40. XM_017593839.1 → XP_017449328.1  protein 4.1 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A4E3
      Related
      ENSRNOP00000085800.2, ENSRNOT00000112187.2

    41. XM_017593836.1 → XP_017449325.1  protein 4.1 isoform X9

      UniProtKB/TrEMBL
      D3ZIP3, D4A9A6
      Related
      ENSRNOP00000075428.3, ENSRNOT00000079935.3

    42. XM_017593830.1 → XP_017449319.1  protein 4.1 isoform X2

      UniProtKB/TrEMBL
      A6ISR5

    43. XM_017593835.1 → XP_017449324.1  protein 4.1 isoform X8

      UniProtKB/TrEMBL
      D4A9A6
      Related
      ENSRNOP00000013761.5, ENSRNOT00000013761.8

    44. XM_017593827.1 → XP_017449316.1  protein 4.1 isoform X1

      UniProtKB/TrEMBL
      A6ISR5

    45. XM_063287541.1 → XP_063143611.1  protein 4.1 isoform X6

      UniProtKB/TrEMBL
      D4A9A6

    46. XM_017593834.1 → XP_017449323.1  protein 4.1 isoform X7

      UniProtKB/TrEMBL
      D4A9A6

    47. XM_039111264.2 → XP_038967192.1  protein 4.1 isoform X21

      UniProtKB/TrEMBL
      A0A0G2K161
      Conserved Domains (4) summary
      smart00295
      Location:210 → 400
      B41; Band 4.1 homologues
      cd13184
      Location:395 → 488
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:657 → 705
      SAB; SAB domain
      pfam08736
      Location:498 → 541
      FA; FERM adjacent (FA)

    48. XM_063287553.1 → XP_063143623.1  protein 4.1 isoform X30

      UniProtKB/TrEMBL
      A0A0G2K161

    49. XM_039111265.2 → XP_038967193.1  protein 4.1 isoform X23

      UniProtKB/TrEMBL
      A0A0G2K161
      Conserved Domains (4) summary
      smart00295
      Location:210 → 400
      B41; Band 4.1 homologues
      cd13184
      Location:395 → 488
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:658 → 706
      SAB; SAB domain
      pfam08736
      Location:498 → 541
      FA; FERM adjacent (FA)

    50. XM_039111263.2 → XP_038967191.1  protein 4.1 isoform X20

      UniProtKB/TrEMBL
      A0A0G2K161
      Related
      ENSRNOP00000071712.3, ENSRNOT00000088493.3
      Conserved Domains (4) summary
      smart00295
      Location:210 → 400
      B41; Band 4.1 homologues
      cd13184
      Location:395 → 488
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:658 → 706
      SAB; SAB domain
      pfam08736
      Location:498 → 541
      FA; FERM adjacent (FA)
    Nucleotide Protein Strain
    Heading Accession and Version

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