Lsm11 LSM11, U7 small nuclear RNA associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lsm11provided by RGD
Official Full Name: LSM11, U7 small nuclear RNA associatedprovided by RGD
Primary source: RGD:1565523
See related: EnsemblRapid:ENSRNOG00000005450 AllianceGenome:RGD:1565523
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565523
Summary: Predicted to enable U7 snRNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage; positive regulation of G1/S transition of mitotic cell cycle; and regulation of chromatin organization. Predicted to be located in nuclear body. Predicted to be part of U7 snRNP; histone pre-mRNA 3'end processing complex; and telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human LSM11 (LSM11, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 82.2), Heart (RPKM 42.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (30869168..30887275, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (30367841..30385956, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (31023561..31041700, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH133067 (e-PCR)
- UniSTS:216350

RH136783 (e-PCR)
- UniSTS:218872

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables U7 snRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U7 snRNP	ISO Inferred from Sequence Orthology more info
part_of histone pre-mRNA 3'end processing complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: U7 snRNA-associated Sm-like protein LSm11

Names: U7 snRNP-specific Sm-like protein LSM11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173384.1 → NP_001166855.1 U7 snRNA-associated Sm-like protein LSm11

See identical proteins and their annotated locations for NP_001166855.1

Status: PROVISIONAL

Source sequence(s)

BC158836

UniProtKB/TrEMBL

A6HDQ3, B0BNI4, F7FQ27

Related

ENSRNOP00000007267.4, ENSRNOT00000007267.8

Conserved Domains (1) summary

cd01739
Location:160 → 225

LSm11_M; Like-Sm protein 11, middle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

30869168..30887275 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246151.5 → XP_006246213.1 U7 snRNA-associated Sm-like protein LSm11 isoform X1

Related

ENSRNOP00000111519.1, ENSRNOT00000147861.1

Conserved Domains (1) summary

cl00259
Location:160 → 198

Sm_like; Sm and related proteins