Rims3 regulating synaptic membrane exocytosis 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rims3provided by RGD
Official Full Name: regulating synaptic membrane exocytosis 3provided by RGD
Primary source: RGD:628762
See related: EnsemblRapid:ENSRNOG00000011171 AllianceGenome:RGD:628762
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nim2; Nim3; RIM 3
Summary: Predicted to enable transmembrane transporter binding activity. Predicted to be a structural constituent of presynaptic active zone. Involved in calcium-ion regulated exocytosis and regulation of synapse organization. Acts upstream of or within regulation of synaptic vesicle exocytosis. Is active in glutamatergic synapse and postsynaptic cytosol. Orthologous to human RIMS3 (regulating synaptic membrane exocytosis 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 87.7) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (139714302..139754145)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (134429092..134468935)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (139790395..139819014)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gamma-RIMs are involved in cell biological functions distinct from the regulation of synaptic vesicle exocytosis and play a role in the molecular mechanisms controlling the establishment of dendritic complexity and axonal outgrowth
Title: RIM3γ and RIM4γ are key regulators of neuronal arborization.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:493179

RH130458 (e-PCR)
- UniSTS:213742

d5rat169 (e-PCR)
- UniSTS:122108

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium-ion regulated exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in maintenance of presynaptic active zone structure	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: regulating synaptic membrane exocytosis protein 3

Names: RIM3 gamma; rab-3-interacting molecule 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430103.1 → NP_001417032.1 regulating synaptic membrane exocytosis protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9JIR3

UniProtKB/TrEMBL

A6IRZ7, G3V7H4
NM_022931.3 → NP_075220.2 regulating synaptic membrane exocytosis protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9JIR3

UniProtKB/TrEMBL

A6IRZ7, G3V7H4

Related

ENSRNOP00000098261.1, ENSRNOT00000120626.2

Conserved Domains (1) summary

cl14603
Location:140 → 285

C2; C2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

139714302..139754145

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110727.2 → XP_038966655.1 regulating synaptic membrane exocytosis protein 3 isoform X1

Conserved Domains (1) summary

cl14603
Location:140 → 285

C2; C2 domain