Frg1 FSHD region gene 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Frg1provided by RGD
Official Full Name: FSHD region gene 1provided by RGD
Primary source: RGD:1585495
See related: EnsemblRapid:ENSRNOG00000009846 AllianceGenome:RGD:1585495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in muscle organ development. Predicted to be located in membrane. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleolus and striated muscle dense body. Orthologous to human FRG1 (FSHD region gene 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 186.7), Spleen (RPKM 150.3) and 9 other tissues See more
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Genomic context

Location:: 16q12.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (57629221..57650188)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (50925783..50946661)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (53957858..53978865)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in striated muscle dense body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein FRG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290133.1 → NP_001277062.1 protein FRG1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6AIP8, A6J0V5, D3ZZK8

Related

ENSRNOP00000013078.7, ENSRNOT00000013078.9

Conserved Domains (1) summary

pfam06229
Location:67 → 256

FRG1; FRG1-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

57629221..57650188

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094827.2 → XP_038950755.1 protein FRG1 isoform X1

UniProtKB/TrEMBL

A0A8I6AIP8, A6J0V5

Conserved Domains (1) summary

pfam06229
Location:67 → 215

FRG1; FRG1-like domain
XM_039094828.2 → XP_038950756.1 protein FRG1 isoform X2

Conserved Domains (1) summary

pfam06229
Location:4 → 193

FRG1; FRG1-like domain