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    Hyi hydroxypyruvate isomerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hyiprovided by RGD
    Official Full Name
    hydroxypyruvate isomeraseprovided by RGD
    Primary source
    RGD:1561416
    See related
    EnsemblRapid:ENSRNOG00000037518 AllianceGenome:RGD:1561416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561416
    Summary
    Predicted to enable hydroxypyruvate isomerase activity. Predicted to be involved in glyoxylate metabolic process. Orthologous to human HYI (hydroxypyruvate isomerase (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 331.5), Kidney (RPKM 173.5) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hyi in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (137179975..137182654)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131894575..131897709)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (137189440..137192125)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 4A Neighboring gene protein tyrosine phosphatase, receptor type, F Neighboring gene uncharacterized LOC102553423 Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene mediator complex subunit 8 Neighboring gene ELOVL fatty acid elongase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydroxypyruvate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glyoxylate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative hydroxypyruvate isomerase
    NP_001385769.1
    XP_006238809.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398840.1 → NP_001385769.1  putative hydroxypyruvate isomerase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1LZJ4
      Related
      ENSRNOP00000053659.2, ENSRNOT00000056815.5
      Conserved Domains (1) summary
      COG3622
      Location:3 → 266
      Hyi; Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      137179975..137182654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238747.5 → XP_006238809.1  putative hydroxypyruvate isomerase isoform X1

      UniProtKB/TrEMBL
      A6JZG7
      Conserved Domains (1) summary
      pfam01261
      Location:24 → 206
      AP_endonuc_2; Xylose isomerase-like TIM barrel
    Nucleotide Protein Strain
    Heading Accession and Version

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